Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | CASP3 | P42574 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | NR2F2 | P24468 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.44 |
| ▸ | XBP1 | P17861 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.43 |
| ▸ | NOS1 | P29475 | 1/20 | 0.42 |
| ▸ | NOS2 | P35228 | 1/20 | 0.42 |
| ▸ | FAAH | O00519 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21143992 | 0.86 | IDH1 (0.40) | ALOX15S1PR2OPRK1NOS1NOS2 | |
| SCHEMBL15615320 | 0.81 | NOS2 (0.52) | MEN1KMT2ANPSR1ALDH1A1LMNA | |
| SCHEMBL17084453 | 0.79 | ALOX15 (0.48) | ALOX15CASP3MEN1KMT2ANR2F2 | |
| SCHEMBL15615316 | 0.77 | KMT2A (0.48) | ALOX15MEN1KMT2AALDH1A1S1PR2 | |
| SCHEMBL24759432 | 0.74 | KDM4E (0.45) | KMT2ANPSR1ALDH1A1LMNAKDM4E | |
| SCHEMBL496019 | 0.73 | NR2F2 (0.53) | ALOX15TDP1CASP3MEN1KMT2A | |
| SCHEMBL3037603 | 0.72 | S1PR1 (0.56) | ALOX15MEN1KMT2A | |
| SCHEMBL3124028 | 0.72 | MEN1 (0.54) | TDP1MEN1KMT2AALDH1A1LMNA | |
| SCHEMBL21949165 | 0.72 | ALOX15 (0.55) | ALOX15MEN1KMT2ANR2F2NPSR1 | |
| SCHEMBL2773911 | 0.71 | S1PR1 (0.54) | ALOX15MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170182049-A1 | NOVEL THERAPEUTICS FOR BRAIN CANCER | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2017-06-29 | — | — | US | disclosed |
| US-20150259326-A1 | NOVEL THERAPEUTICS FOR BRAIN CANCER | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2015-09-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150259326-A1 | NOVEL THERAPEUTICS FOR BRAIN CANCER | ING2, GMFG, PLP2 | ALOX15 3197/4885TDP1 3722/4885CASP3 3626/4885 |
| US-20170182049-A1 | NOVEL THERAPEUTICS FOR BRAIN CANCER | ING2, GMFG, PLP2 | ALOX15 3197/4885TDP1 3722/4885CASP3 3626/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.