Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK2 | Q05397 | 3/20 | 0.50 |
| ▸ | EGFR | P00533 | 12/20 | 0.49 |
| ▸ | ZAP70 | P43403 | 2/20 | 0.48 |
| ▸ | ROS1 | P08922 | 1/20 | 0.42 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.42 |
| ▸ | MET | P08581 | 1/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.42 |
| ▸ | ULK1 | O75385 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1707277 | 0.84 | ZAP70 (0.46) | PTK2EGFRZAP70ROS1ALK | |
| SCHEMBL600898 | 0.83 | GLO1 (0.51) | PTK2EGFRROS1ALKMET | |
| SCHEMBL1707698 | 0.81 | PTK2 (0.64) | PTK2EGFRZAP70ROS1ALK | |
| SCHEMBL1707654 | 0.79 | ZAP70 (0.73) | PTK2EGFRZAP70ROS1ALK | |
| SCHEMBL21847030 | 0.79 | PTK2 (0.55) | PTK2EGFRALKMETLRRK2 | |
| SCHEMBL29190684 | 0.78 | EGFR (0.45) | PTK2EGFRZAP70ALKULK1 | |
| SCHEMBL29190532 | 0.78 | EGFR (0.45) | PTK2EGFRZAP70ALKMET | |
| SCHEMBL1708524 | 0.77 | ZAP70 (0.47) | PTK2EGFRZAP70ALKMET | |
| SCHEMBL1707782 | 0.75 | ZAP70 (0.59) | PTK2EGFRZAP70ROS1ALK | |
| SCHEMBL25381727 | 0.75 | EGFR (0.43) | PTK2EGFRZAP70METLRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120142667-A1 | PYRIMIDINE DERIVATIVES AS ZAP-70 INHIBITORS | CELLZOME LIMITED (GB) | 2012-06-07 | — | — | US | disclosed |
| EP-2440534-A2 | PYRIMIDINE DERIVATIVES AS ZAP-70 INHIBITORS | Cellzome Limited (GB) | 2012-04-18 | — | — | EP | disclosed |
| WO-2010142766-A2 | PYRIMIDINE DERIVATIVES AS ZAP-70 INHIBITORS | CELLZOME LIMITED (GB) | 2010-12-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120142667-A1 | PYRIMIDINE DERIVATIVES AS ZAP-70 INHIBITORS | ZAP70, LCK, DPY30 | PTK2 1584/4885EGFR 3420/4885ZAP70 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.