Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | LIN28A | Q9H9Z2 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL172599 | 0.87 | TDP1 (0.50) | TDP1MAPTSMN1; SMN2LIN28AKDM4E | |
| SCHEMBL13999364 | 0.84 | TSHR (0.50) | TDP1MAPTSMN1; SMN2KDM4ETSHR | |
| SCHEMBL23137023 | 0.83 | TDP1 (0.46) | TDP1MAPTSMN1; SMN2LIN28AKDM4E | |
| SCHEMBL13995680 | 0.82 | TDP1 (0.49) | TDP1MAPTSMN1; SMN2LIN28AKDM4E | |
| SCHEMBL13995302 | 0.82 | TDP1 (0.49) | TDP1MAPTSMN1; SMN2LIN28AKDM4E | |
| SCHEMBL13995694 | 0.82 | TDP1 (0.49) | TDP1MAPTSMN1; SMN2LIN28AKDM4E | |
| SCHEMBL12089127 | 0.81 | TDP1 (0.55) | TDP1MAPTSMN1; SMN2LIN28AKDM4E | |
| SCHEMBL7093038 | 0.78 | TDP1 (0.52) | TDP1MAPTSMN1; SMN2LIN28AKDM4E | |
| SCHEMBL7035519 | 0.75 | TSHR (0.49) | TDP1MAPTSMN1; SMN2LIN28ATSHR | |
| SCHEMBL19333396 | 0.75 | TDP1 (0.42) | TDP1MAPTSMN1; SMN2LIN28AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1255738-B1 | GONADOTROPIN-RELEASING HORMONE RECEPTOR ANTAGONISTS AND METHODS RELATING THERETO | NEUROCRINE BIOSCIENCES INC (US) | 2012-03-07 | — | — | EP | disclosed |