Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 2/20 | 0.44 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MGLL | Q99685 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | GRIA2 | P42262 | 3/20 | 0.36 |
| ▸ | CTSD | P07339 | 1/20 | 0.36 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
| ▸ | AKT1 | P31749 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17090339 | 0.86 | PTPN1 (0.46) | PTPN1MDM2KMT2AMGLLHPGD | |
| SCHEMBL13565852 | 0.86 | MDM2 (0.43) | MDM2KMT2AHPGDSMN1; SMN2GRIA2 | |
| SCHEMBL10114104 | 0.84 | MDM2 (0.50) | PTPN1MDM2KMT2AMGLLSMN1; SMN2 | |
| SCHEMBL10113969 | 0.77 | MDM2 (0.71) | PTPN1MDM2KMT2ASMN1; SMN2GRIA2 | |
| SCHEMBL11935111 | 0.76 | CXCR4 (0.45) | KMT2ASMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL13565076 | 0.76 | GRIA2 (0.35) | KMT2AGRIA2 | |
| SCHEMBL17089983 | 0.76 | PTPN1 (0.45) | PTPN1KMT2AMGLLPKMPOLB | |
| SCHEMBL13565273 | 0.76 | GRIA2 (0.45) | GRIA2ALDH1A1 | |
| SCHEMBL13565060 | 0.76 | KDM4E (0.41) | KMT2ASMN1; SMN2GRIA2NPC1RAB9A | |
| SCHEMBL13564823 | 0.72 | NPY5R (0.60) | GRIA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9139518-B2 | Amine derivative having NPY Y5 receptor antagonistic activity | SHIONOGI & CO., LTD. (JP) | 2015-09-22 | — | — | US | disclosed |