Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA4 | P48058 | 1/20 | 0.47 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.47 |
| ▸ | GRIA2 | P42262 | 7/20 | 0.43 |
| ▸ | NPY5R | Q15761 | 7/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13565889 | 1.00 | GRIA4 (0.47) | GRIA4CRHR1GRIA2NPY5RKDM4E | |
| SCHEMBL17090434 | 0.88 | GRIA4 (0.46) | GRIA4GRIA2NPY5R | |
| SCHEMBL13565462 | 0.88 | GRIA4 (0.46) | GRIA4GRIA2NPY5R | |
| SCHEMBL11935097 | 0.87 | GRIA2 (0.43) | GRIA4CRHR1GRIA2NPY5R | |
| SCHEMBL13564821 | 0.86 | GRIA2 (0.43) | CRHR1GRIA2NPY5R | |
| SCHEMBL13565050 | 0.86 | CRHR1 (0.50) | CRHR1GRIA2NPY5R | |
| SCHEMBL17090148 | 0.86 | CRHR1 (0.50) | CRHR1GRIA2NPY5R | |
| SCHEMBL13439116 | 0.86 | GRIA2 (0.43) | GRIA4CRHR1GRIA2NPY5R | |
| SCHEMBL13565239 | 0.85 | CRHR1 (0.47) | CRHR1GRIA2NPY5RKDM4E | |
| SCHEMBL17090027 | 0.85 | CRHR1 (0.47) | CRHR1GRIA2NPY5RKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9139518-B2 | Amine derivative having NPY Y5 receptor antagonistic activity | SHIONOGI & CO., LTD. (JP) | 2015-09-22 | — | — | US | disclosed |