Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 3/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | GRIA2 | P42262 | 4/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | IDH2 | P48735 | 3/20 | 0.42 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.42 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17090027 | 1.00 | CRHR1 (0.47) | CRHR1RXFP1GRIA2KCNH2IDH2 | |
| SCHEMBL11935326 | 0.86 | CRHR1 (0.43) | CRHR1GRIA2NPY5R | |
| SCHEMBL11936150 | 0.86 | CRHR1 (0.43) | CRHR1GRIA2NPY5R | |
| SCHEMBL13438988 | 0.85 | CRHR1 (0.48) | CRHR1RXFP1IDH2NPY5RTRPV4 | |
| SCHEMBL17090145 | 0.85 | GRIA4 (0.47) | CRHR1GRIA2NPY5RKDM4E | |
| SCHEMBL13565889 | 0.85 | GRIA4 (0.47) | CRHR1GRIA2NPY5RKDM4E | |
| SCHEMBL11936202 | 0.84 | SLC6A9 (0.41) | GRIA2KCNH2 | |
| SCHEMBL11935097 | 0.84 | GRIA2 (0.43) | CRHR1GRIA2NPY5R | |
| SCHEMBL13565050 | 0.83 | CRHR1 (0.50) | CRHR1GRIA2NPY5R | |
| SCHEMBL13439116 | 0.83 | GRIA2 (0.43) | CRHR1GRIA2NPY5R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8299265-B2 | Amine derivatives having NPY Y5 receptor antagonistic activity and the uses thereof | SHIONOGI & CO., LTD. (JP) | 2012-10-30 | — | — | US | disclosed |