Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | BACE1 | P56817 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 3/20 | 0.38 |
| ▸ | PKM | P14618 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13565098 | 1.00 | GAA (0.44) | GAAACHEBACE1SMN1; SMN2MAPT | |
| SCHEMBL17090013 | 0.90 | ACHE (0.49) | ACHEBACE1SMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL13565941 | 0.90 | ACHE (0.49) | ACHEBACE1SMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL17090237 | 0.88 | NPY5R (0.38) | — | |
| SCHEMBL13565909 | 0.88 | NPY5R (0.38) | — | |
| SCHEMBL13565158 | 0.87 | KMT2A (0.46) | GAAACHEBACE1ALDH1A1L3MBTL1 | |
| SCHEMBL17090018 | 0.87 | KMT2A (0.46) | GAAACHEBACE1ALDH1A1L3MBTL1 | |
| SCHEMBL13564856 | 0.85 | ACHE (0.42) | GAAACHEBACE1SMN1; SMN2MAPT | |
| SCHEMBL17090107 | 0.85 | ACHE (0.42) | GAAACHEBACE1SMN1; SMN2MAPT | |
| SCHEMBL13566011 | 0.83 | ALDH1A1 (0.43) | GAAMAPTALDH1A1TSHRTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9139518-B2 | Amine derivative having NPY Y5 receptor antagonistic activity | SHIONOGI & CO., LTD. (JP) | 2015-09-22 | — | — | US | disclosed |