Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 2/20 | 0.36 |
| ▸ | CNR2 | P34972 | 2/20 | 0.36 |
| ▸ | NPY5R | Q15761 | 4/20 | 0.35 |
| ▸ | HTR2A | P28223 | 5/20 | 0.34 |
| ▸ | DRD3 | P35462 | 5/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | WDR5 | P61964 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13565620 | 1.00 | CNR1 (0.36) | CNR1CNR2NPY5RHTR2ADRD3 | |
| SCHEMBL13564888 | 0.88 | NPY5R (0.43) | CNR1CNR2NPY5R | |
| SCHEMBL17090229 | 0.88 | NPY5R (0.43) | CNR1CNR2NPY5R | |
| SCHEMBL13565760 | 0.87 | USP30 (0.33) | CNR1CNR2NPY5RHTR2ADRD3 | |
| SCHEMBL17089993 | 0.87 | USP30 (0.33) | CNR1CNR2NPY5RHTR2ADRD3 | |
| SCHEMBL17090183 | 0.85 | LRRK2 (0.35) | CNR1CNR2HTR2ADRD3 | |
| SCHEMBL13565047 | 0.85 | LRRK2 (0.35) | CNR1CNR2HTR2ADRD3 | |
| SCHEMBL13565030 | 0.83 | USP30 (0.39) | CNR2 | |
| SCHEMBL17089990 | 0.82 | BRD4 (0.35) | HTR2ADRD3ALDH1A1 | |
| SCHEMBL13565697 | 0.82 | BRD4 (0.35) | HTR2ADRD3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9139518-B2 | Amine derivative having NPY Y5 receptor antagonistic activity | SHIONOGI & CO., LTD. (JP) | 2015-09-22 | — | — | US | disclosed |