Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | SHBG | P04278 | 1/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23275968 | 0.96 | LMNA (0.43) | KDM4ELMNACNR1ADRA1ATDP1 | |
| SCHEMBL23275966 | 0.96 | LMNA (0.43) | KDM4ELMNACNR1ADRA1ATDP1 | |
| SCHEMBL7776985 | 0.86 | KDM4E (0.52) | KDM4EALDH1A1SHBGEPHX1SLC6A4 | |
| SCHEMBL29223954 | 0.84 | KDM4E (0.43) | KDM4ESMN1; SMN2ALDH1A1EPHX1ADRB2 | |
| SCHEMBL1148861 | 0.84 | KDM4E (0.50) | KDM4EALDH1A1SHBGEPHX1SLC6A4 | |
| SCHEMBL7775156 | 0.84 | KDM4E (0.50) | KDM4EALDH1A1SHBGEPHX1SLC6A4 | |
| Ammonia Solution, Strong SCHEMBL29224616 | 0.82 | KDM4E (0.41) | KDM4ESMN1; SMN2ALDH1A1EPHX1ADRB2 | |
| Ammonia Solution, Strong SCHEMBL342936 | 0.82 | KDM4E (0.48) | KDM4EALDH1A1SHBGEPHX1SLC6A4 | |
| SCHEMBL27572081 | 0.80 | MEN1 (0.42) | ALDH1A1EPHX1EPHX2MEN1KMT2A | |
| SCHEMBL20144701 | 0.79 | ALDH1A1 (0.43) | KDM4ELMNACNR1ADRA1ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1255738-B1 | GONADOTROPIN-RELEASING HORMONE RECEPTOR ANTAGONISTS AND METHODS RELATING THERETO | NEUROCRINE BIOSCIENCES INC (US) | 2012-03-07 | — | — | EP | disclosed |