Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 6/20 | 0.39 |
| ▸ | DRD3 | P35462 | 6/20 | 0.39 |
| ▸ | DRD2 | P14416 | 5/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.33 |
| ▸ | MET | P08581 | 1/20 | 0.33 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | PDE4A | P27815 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13565472 | 0.87 | GRIA2 (0.35) | SYKLMNANPY5R | |
| SCHEMBL13439186 | 0.80 | SYK (0.41) | SYKLMNAPDE4APDE4BPDE4C | |
| SCHEMBL11935442 | 0.80 | SYK (0.41) | SYKLMNAPDE4APDE4BPDE4C | |
| SCHEMBL11936231 | 0.72 | DRD2 (0.46) | HTR2ADRD3DRD2NPY5RMET | |
| SCHEMBL11936181 | 0.71 | DRD2 (0.43) | HTR2ADRD3DRD2SYKNPY5R | |
| SCHEMBL13565404 | 0.70 | DRD2 (0.38) | HTR2ADRD3DRD2NPY5RMET | |
| SCHEMBL17090401 | 0.70 | GRIA2 (0.36) | HTR2ADRD3DRD2NPY5R | |
| SCHEMBL13438989 | 0.70 | DRD2 (0.38) | HTR2ADRD3DRD2NPY5RMET | |
| SCHEMBL11936207 | 0.70 | ALDH1A1 (0.43) | HTR2ADRD3DRD2SYKLMNA | |
| SCHEMBL17089967 | 0.70 | DRD2 (0.38) | HTR2ADRD3DRD2NPY5RMET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9139518-B2 | Amine derivative having NPY Y5 receptor antagonistic activity | SHIONOGI & CO., LTD. (JP) | 2015-09-22 | — | — | US | disclosed |