Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA1 | P42261 | 3/20 | 0.46 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | NPY5R | Q15761 | 6/20 | 0.40 |
| ▸ | HTR1A | P08908 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | PNMT | P11086 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13439320 | 0.86 | HTR2B (0.39) | HTR2BLMNASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL11935824 | 0.85 | HTR2B (0.45) | HTR2BLMNASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL17090440 | 0.85 | GRIA1 (0.51) | GRIA1NPY5RLMNASMN1; SMN2KDM4E | |
| SCHEMBL13565927 | 0.83 | ALDH1A1 (0.47) | LMNASMN1; SMN2KDM4EALDH1A1KMT2A | |
| SCHEMBL10115437 | 0.83 | ALDH1A1 (0.53) | HTR2BHTR1ALMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL11935749 | 0.81 | GRIA1 (0.53) | GRIA1NPY5RHTR1AALDH1A1 | |
| SCHEMBL13565339 | 0.81 | GRIA1 (0.53) | GRIA1NPY5RHTR1AALDH1A1PKM | |
| SCHEMBL11935832 | 0.81 | ALDH1A1 (0.53) | LMNASMN1; SMN2ALDH1A1L3MBTL1KMT2A | |
| SCHEMBL13565562 | 0.80 | GRIA1 (0.51) | GRIA1NPY5RHTR1AKMT2A | |
| SCHEMBL13565857 | 0.80 | GRIA1 (0.51) | GRIA1NPY5RHTR1AALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9139518-B2 | Amine derivative having NPY Y5 receptor antagonistic activity | SHIONOGI & CO., LTD. (JP) | 2015-09-22 | — | — | US | disclosed |