Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | TMPRSS4 | Q9NRS4 | 2/20 | 0.49 |
| ▸ | KDR | P35968 | 2/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.42 |
| ▸ | PDE2A | O00408 | 2/20 | 0.42 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | KIF11 | P52732 | 1/20 | 0.39 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11406449 | 0.83 | KIF11 (0.46) | MEN1KMT2ATSHRTMPRSS4TRPV1 | |
| SCHEMBL9226482 | 0.79 | MEN1 (0.47) | MEN1KMT2ATSHRTMPRSS4KDR | |
| SCHEMBL21621721 | 0.79 | MEN1 (0.47) | MEN1KMT2ATSHRTMPRSS4KDR | |
| SCHEMBL19661475 | 0.78 | ALDH1A1 (0.46) | MEN1KMT2ATSHRBACE1KIF11 | |
| Hydrochloric Acid SCHEMBL3640197 | 0.78 | IDO1 (0.47) | MEN1KMT2ATSHRTMPRSS4KDR | |
| SCHEMBL17671209 | 0.78 | HDAC1 (0.54) | MEN1KMT2ATRPV1CHRNA7 | |
| SCHEMBL3618813 | 0.77 | MEN1 (0.61) | MEN1KMT2ATSHRTMPRSS4KDR | |
| SCHEMBL20656065 | 0.76 | MEN1 (0.45) | MEN1KMT2ATSHRTMPRSS4KDR | |
| SCHEMBL20560277 | 0.76 | MEN1 (0.55) | MEN1KMT2ATSHRTMPRSS4KDR | |
| SCHEMBL5518568 | 0.76 | MEN1 (0.55) | MEN1KMT2ATSHRTMPRSS4KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2426108-B1 | Processes and intermediates for preparing fused heterocyclic kinase inhibitors | METHYLGENE INC (CA) | 2016-08-10 | — | — | EP | disclosed |
| EP-2426122-A1 | Methylene urea derivative as RAF kinasse inhibitors | Merck Patent GmbH (DE) | 2012-03-07 | — | — | EP | disclosed |