SCHEMBL1709090

SCHEMBL1709090

NC[C@H](O)[C@@H](O)[C@H](O)CCO

nearest known ligand 0.38

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
THRB P10828 1/20 0.35
LMNA P02545 1/20 0.32
L3MBTL1 Q9Y468 1/20 0.32
TDP1 Q9NUW8 1/20 0.30
ALDH1A1 P00352 1/20 0.30
TSHR P16473 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22400059 1.00 THRB (0.35) THRBLMNAL3MBTL1TDP1ALDH1A1
SCHEMBL18541625 1.00 THRB (0.35) THRBLMNAL3MBTL1TDP1ALDH1A1
SCHEMBL20804121 1.00 THRB (0.35) THRBLMNAL3MBTL1TDP1ALDH1A1
SCHEMBL23822904 1.00 THRB (0.35) THRBLMNAL3MBTL1TDP1ALDH1A1
SCHEMBL14280356 1.00 THRB (0.35) THRBLMNAL3MBTL1TDP1ALDH1A1
SCHEMBL23226272 1.00 THRB (0.35) THRBLMNAL3MBTL1TDP1ALDH1A1
SCHEMBL18541617 1.00 THRB (0.35) THRBLMNAL3MBTL1TDP1ALDH1A1
SCHEMBL15484277 0.85 THRB (0.44) THRBLMNAL3MBTL1TDP1ALDH1A1
SCHEMBL22641547 0.83 ALDH1A1 (0.37) THRBLMNAL3MBTL1TDP1ALDH1A1
SCHEMBL9009380 0.82

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2021060395-A1 SUSTAINED-RELEASE PHARMACEUTICAL COMPOSITION 持田製薬株式会社 2021-04-01 WO disclosed
WO-2020242943-A1 GPR40 AGONISTS KALLYOPE, INC. (US) 2020-12-03 WO disclosed
EP-2139523-B1 CONJUGATES OF FOLATE AND TUBULYSIN FOR TARGETED DRUG DELIVERY ENDOCYTE INC (US) 2014-10-22 EP disclosed
WO-2014085575-A1 METHODS FOR TREATING CANCER USING COMBINATION THERAPIES ENDOCYTE, INC. (US) 2014-06-05 WO disclosed
EP-2489372-A2 Binding ligand linked drug delivery conjugates of tubulysins Endocyte, Inc. (US) 2012-08-22 EP disclosed
EP-2481427-A1 Folate-Tubulysin conjugates Endocyte, Inc. (US) 2012-08-01 EP disclosed
WO-2012047525-A2 FOLATE CONJUGATES FOR TREATING INFLAMMATION OF THE EYE ENDOCYTE, INC. (US) 2012-04-12 WO disclosed
WO-2011079227-A1 VITAMIN RECEPTOR DRUG DELIVERY CONJUGATES FOR TREATING INFLAMMATION ENDOCYTE, INC. (US) 2011-06-30 WO disclosed
WO-2009002993-A1 CONJUGATES CONTAINING HYDROPHILIC SPACER LINKERS ENDOCYTE, INC. (US) 2008-12-31 WO disclosed
WO-2008112873-A2 BINDING LIGAND LINKED DRUG DELIVERY CONJUGATES OF TUBULYSINS ENDOCYTE, INC. (US) 2008-09-18 WO disclosed