Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB8 | P28062 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | CSF1R | P07333 | 1/20 | 0.42 |
| ▸ | FLT3 | P36888 | 1/20 | 0.42 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.42 |
| ▸ | CTSA | P10619 | 2/20 | 0.42 |
| ▸ | MMP13 | P45452 | 1/20 | 0.40 |
| ▸ | ALKBH2 | Q6NS38 | 1/20 | 0.40 |
| ▸ | ALKBH3 | Q96Q83 | 1/20 | 0.40 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.40 |
| ▸ | ANO1 | Q5XXA6 | 3/20 | 0.40 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.39 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL168844 | 0.82 | MAOB (0.51) | PSMB8MEN1KMT2AFLT3LOXL2 | |
| SCHEMBL13852609 | 0.82 | KMT2A (0.52) | PSMB8MEN1KMT2ACTSAMMP13 | |
| SCHEMBL13602358 | 0.80 | KMT2A (0.53) | PSMB8MEN1KMT2AFLT3CTSA | |
| SCHEMBL171084 | 0.78 | HPGD (0.50) | PSMB8MEN1KMT2ALOXL2CTSA | |
| SCHEMBL170923 | 0.78 | KMT2A (0.47) | PSMB8MEN1KMT2ALOXL2CTSA | |
| SCHEMBL10274536 | 0.77 | KMT2A (0.50) | PSMB8MEN1KMT2ACSF1RFLT3 | |
| SCHEMBL170568 | 0.77 | HTT (0.57) | PSMB8MEN1KMT2AFLT3CTSA | |
| SCHEMBL107759 | 0.77 | CTSA (0.50) | MEN1KMT2ACSF1RFLT3CTSA | |
| SCHEMBL24405150 | 0.75 | EGLN1 (0.49) | PSMB8MEN1KMT2ACSF1RFLT3 | |
| SCHEMBL10274537 | 0.75 | LOXL2 (0.66) | PSMB8MEN1KMT2ACSF1RFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2426122-A1 | Methylene urea derivative as RAF kinasse inhibitors | Merck Patent GmbH (DE) | 2012-03-07 | — | — | EP | disclosed |