Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | TAOK3 | Q9H2K8 | 2/20 | 0.42 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6253566 | 0.72 | KDM4E (0.56) | DRD2ALDH1A1LMNAMAPTTAOK3 | |
| SCHEMBL10072038 | 0.69 | SCN9A (0.53) | SCN9AALDH1A1LMNAKMT2AMEN1 | |
| SCHEMBL6258055 | 0.69 | EPHX1 (0.52) | ALDH1A1LMNAKMT2AMEN1HTT | |
| SCHEMBL13936472 | 0.67 | ALDH1A1 (0.86) | DRD2ALDH1A1LMNAMAPTTAOK3 | |
| SCHEMBL2115700 | 0.67 | HTT (0.63) | ALDH1A1LMNAKMT2AMEN1HTT | |
| SCHEMBL6252685 | 0.67 | KDM4E (0.65) | ALDH1A1KMT2AMEN1HTTKDM4E | |
| SCHEMBL2704412 | 0.67 | KDM4E (0.65) | ALDH1A1KMT2AMEN1HTTKDM4E | |
| SCHEMBL1327514 | 0.66 | HTT (0.56) | ALDH1A1LMNAKMT2AMEN1HTT | |
| SCHEMBL1327511 | 0.66 | HTT (0.56) | ALDH1A1LMNAKMT2AMEN1HTT | |
| SCHEMBL14930299 | 0.66 | HTT (0.56) | ALDH1A1LMNAKMT2AMEN1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012047703-A2 | CYCLOPROPYL-SPIRO-PIPERIDINES USEFUL AS SODIUM CHANNEL BLOCKERS | SCHERING CORPORATION (US) | 2012-04-12 | — | — | WO | disclosed |