Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 5/20 | 0.53 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 3/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 3/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1709241 | 0.74 | SCN9A (0.54) | SCN9AHRH3HTR7CYP3A4MAPK1 | |
| SCHEMBL1709243 | 0.73 | SCN9A (0.52) | SCN9ACYP3A4MEN1MAPK1CYP2C19 | |
| SCHEMBL1709240 | 0.72 | SCN9A (0.60) | SCN9ACYP3A4MEN1MAPK1CYP2C19 | |
| SCHEMBL1709237 | 0.71 | SCN9A (0.58) | SCN9A | |
| SCHEMBL1709238 | 0.70 | SCN9A (0.59) | SCN9AHTR7KMT2ALMNAALDH1A1 | |
| SCHEMBL1709217 | 0.70 | SCN9A (0.48) | SCN9AKMT2ALMNATSHRALDH1A1 | |
| SCHEMBL1709252 | 0.70 | SCN9A (0.56) | SCN9AMEN1KMT2ACHRNA7LMNA | |
| SCHEMBL1709251 | 0.70 | SCN9A (0.54) | SCN9AMEN1KMT2AALDH1A1 | |
| SCHEMBL1709242 | 0.69 | OPRL1 (0.47) | SCN9AHRH3CYP2D6CHRM4 | |
| SCHEMBL1709250 | 0.69 | SCN9A (0.47) | SCN9AMEN1KMT2ALMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012047703-A2 | CYCLOPROPYL-SPIRO-PIPERIDINES USEFUL AS SODIUM CHANNEL BLOCKERS | SCHERING CORPORATION (US) | 2012-04-12 | — | — | WO | disclosed |