Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 14/20 | 0.39 |
| ▸ | PSEN2 | P49810 | 14/20 | 0.39 |
| ▸ | APH1B | Q8WW43 | 14/20 | 0.39 |
| ▸ | NCSTN | Q92542 | 14/20 | 0.39 |
| ▸ | APH1A | Q96BI3 | 14/20 | 0.39 |
| ▸ | PSENEN | Q9NZ42 | 14/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.33 |
| ▸ | GPR88 | Q9GZN0 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1709414 | 0.89 | PSEN1 (0.40) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL2320297 | 0.87 | PSEN1 (0.47) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL1709494 | 0.86 | HTR2C (0.35) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL1709450 | 0.85 | HTR2C (0.33) | HTR2C | |
| SCHEMBL10032822 | 0.85 | HTR2C (0.33) | HTR2C | |
| SCHEMBL1709403 | 0.85 | HTR2C (0.34) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL1709443 | 0.85 | HTR2C (0.34) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL1709404 | 0.85 | HTR2C (0.34) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL10033004 | 0.84 | PSEN1 (0.36) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL1709366 | 0.83 | L3MBTL1 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012046771-A1 | CYCLOALKANE COMPOUND | アステラス製薬株式会社 (JP) | 2012-04-12 | — | — | WO | disclosed |