SCHEMBL17099404

SCHEMBL17099404

O=c1ccn([C@]2(F)O[C@H](CO)[C@@H](O)C2(F)F)c(=O)[nH]1

nearest known ligand 0.46

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
SLC28A1 O00337 1/20 0.46
SLC28A2 O43868 1/20 0.46
SLC29A1 Q99808 1/20 0.46
SLC28A3 Q9HAS3 1/20 0.46
CRBN Q96SW2 1/20 0.35
P2RY14 Q15391 1/20 0.35
P2RY6 Q15077 7/20 0.34
P2RY2 P41231 2/20 0.34
POLA1 P09884 1/20 0.34
P2RY4 P51582 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5144346 0.88 SLC28A1 (0.45) SLC28A1SLC28A2SLC29A1SLC28A3CRBN
SCHEMBL27979205 0.87 SLC28A1 (0.44) SLC28A1SLC28A2SLC29A1SLC28A3CRBN
SCHEMBL151327 0.85 SLC28A1 (0.43) SLC28A1SLC28A2SLC29A1SLC28A3P2RY14
SCHEMBL6515764 0.80 SLC28A1 (0.38) SLC28A1SLC28A2SLC29A1SLC28A3CRBN
SCHEMBL98410 0.79 SLC28A1 (0.49) SLC28A1SLC28A2SLC29A1SLC28A3P2RY14
SCHEMBL28176484 0.79 SLC28A1 (0.46) SLC28A1SLC28A2SLC29A1SLC28A3P2RY14
SCHEMBL18880976 0.79 SLC28A1 (0.43) SLC28A1SLC28A2SLC29A1SLC28A3P2RY14
SCHEMBL2337871 0.78 SLC28A1 (0.41) SLC28A1SLC28A2SLC29A1SLC28A3P2RY14
SCHEMBL2337859 0.78 SLC28A1 (0.41) SLC28A1SLC28A2SLC29A1SLC28A3P2RY14
SCHEMBL51723 0.78 SLC28A1 (0.45) SLC28A1SLC28A2SLC29A1SLC28A3P2RY14

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20170081698-A1 SURVIVAL ASSAYS FOR METAKARYOTIC STEM CELLS MASSACHUSETTS INSTITUTE OF TECHNOLOGY 2017-03-23 US disclosed
WO-2015142827-A1 SURVIVAL ASSAYS FOR METAKARYOTIC STEM CELLS MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 2015-09-24 WO disclosed