Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP2 | O95551 | 2/20 | 0.36 |
| ▸ | CMA1 | P23946 | 1/20 | 0.35 |
| ▸ | AHR | P35869 | 1/20 | 0.35 |
| ▸ | GRIA1 | P42261 | 2/20 | 0.34 |
| ▸ | CACNG8 | Q8WXS5 | 2/20 | 0.34 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.33 |
| ▸ | SMYD3 | Q9H7B4 | 4/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.31 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.31 |
| ▸ | DRD2 | P14416 | 1/20 | 0.30 |
| ▸ | DRD1 | P21728 | 1/20 | 0.30 |
| ▸ | DRD4 | P21917 | 1/20 | 0.30 |
| ▸ | DRD5 | P21918 | 1/20 | 0.30 |
| ▸ | DRD3 | P35462 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4297627 | 0.85 | TDP2 (0.46) | TDP2CMA1AHRGRIA1CACNG8 | |
| SCHEMBL31116965 | 0.74 | SMYD3 (0.35) | TDP2GRIA1CACNG8SMYD3HDAC3 | |
| SCHEMBL23612469 | 0.72 | GRIA1 (0.39) | TDP2CMA1AHRGRIA1CACNG8 | |
| SCHEMBL13726349 | 0.71 | KIF11 (0.46) | TDP2 | |
| SCHEMBL8122924 | 0.71 | GRIA1 (0.37) | TDP2AHRGRIA1CACNG8SMYD3 | |
| SCHEMBL31304885 | 0.70 | AHR (0.46) | TDP2CMA1AHR | |
| SCHEMBL1163094 | 0.70 | GRIA1 (0.41) | TDP2CMA1AHRGRIA1CACNG8 | |
| SCHEMBL5498437 | 0.70 | GRIA1 (0.41) | TDP2CMA1AHRGRIA1CACNG8 | |
| SCHEMBL5363780 | 0.70 | TDP2 (0.46) | TDP2CMA1AHRGRIA1CACNG8 | |
| SCHEMBL5373768 | 0.69 | TDP2 (0.49) | TDP2CMA1AHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015143376-A1 | NOVEL COMPOUNDS FOR THE TREATMENT OF CYSTIC FIBROSIS | NIVALIS THERAPEUTICS, INC. (US) | 2015-09-24 | — | — | WO | disclosed |