Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 4/20 | 0.59 |
| ▸ | CA2 | P00918 | 4/20 | 0.59 |
| ▸ | PLK1 | P53350 | 1/20 | 0.59 |
| ▸ | NPC1 | O15118 | 4/20 | 0.56 |
| ▸ | RAB9A | P51151 | 4/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | TP53 | P04637 | 2/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.56 |
| ▸ | F10 | P00742 | 2/20 | 0.53 |
| ▸ | CES2 | O00748 | 1/20 | 0.52 |
| ▸ | CES1 | P23141 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | GAA | P10253 | 3/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11665996 | 0.98 | CA1 (0.61) | CA1CA2PLK1NPC1RAB9A | |
| SCHEMBL11705572 | 0.85 | PLK1 (0.56) | CA1CA2PLK1NPC1RAB9A | |
| SCHEMBL21915125 | 0.85 | ALDH1A1 (0.70) | CA1CA2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL11038788 | 0.82 | ALDH1A1 (0.41) | CA1CA2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL11112693 | 0.80 | CA1 (0.61) | CA1CA2PLK1NPC1RAB9A | |
| SCHEMBL2104786 | 0.79 | KMT2A (0.56) | NPC1RAB9ASMN1; SMN2TP53ALOX15 | |
| SCHEMBL31196532 | 0.79 | CA1 (0.59) | CA1CA2PLK1NPC1RAB9A | |
| SCHEMBL4628703 | 0.77 | ALDH1A1 (0.59) | NPC1RAB9ASMN1; SMN2CES2CES1 | |
| Hydrochloric Acid SCHEMBL8880498 | 0.77 | CA1 (0.96) | CA1CA2PLK1NPC1RAB9A | |
| Hydrochloric Acid SCHEMBL11037223 | 0.77 | PLK1 (0.96) | CA1CA2PLK1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3119394-B1 | COMPOSITIONS AND METHODS COMPRISING 2-(ACYLAMINO)IMIDAZOLES | CURZA GLOBAL LLC (US) | 2021-05-12 | — | — | EP | disclosed |
| US-10493061-B2 | Compositions and methods comprising 2-(acylamino)imidazoles | CURZA GLOBAL, LLC (US) | 2019-12-03 | — | — | US | disclosed |
| US-20170100375-A1 | COMPOSITIONS AND METHODS COMPRISING 2-(ACYLAMINO)IMIDAZOLES | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2017-04-13 | — | — | US | disclosed |
| EP-3119394-A2 | COMPOSITIONS AND METHODS COMPRISING 2-(ACYLAMINO)IMIDAZOLES | Curza Global LLC (US) | 2017-01-25 | — | — | EP | disclosed |
| WO-2015143240-A2 | COMPOSITIONS AND METHODS COMPRISING 2-(ACYLAMINO)IMIDAZOLES | CURZA GLOBAL, LLC (US) | 2015-09-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10493061-B2 | Compositions and methods comprising 2-(acylamino)imidazoles | AADAC, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, HDAC6 | CA1 1075/4885CA2 402/4885PLK1 308/4885 |
| US-20170100375-A1 | COMPOSITIONS AND METHODS COMPRISING 2-(ACYLAMINO)IMIDAZOLES | AADAC, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, HDAC6 | CA1 1075/4885CA2 402/4885PLK1 308/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.