SCHEMBL17101059

SCHEMBL17101059

O=C(CN1CCOCC1)Nc1cc(C(=O)Nc2cnc(Cl)cn2)ccc1OC(F)(F)F

nearest known ligand 0.74

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
▸ WNT3A P56704 20/20 0.74

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17101041 0.90 WNT3A (0.74) WNT3A
SCHEMBL16098950 0.88 WNT3A (0.77) WNT3A
SCHEMBL17107956 0.88 WNT3A (0.71) WNT3A
SCHEMBL17101096 0.87 WNT3A (0.70) WNT3A
SCHEMBL17101546 0.87 WNT3A (0.78) WNT3A
SCHEMBL17101076 0.87 WNT3A (0.82) WNT3A
SCHEMBL17101034 0.87 WNT3A (0.72) WNT3A
SCHEMBL17101072 0.86 WNT3A (0.71) WNT3A
SCHEMBL17101049 0.86 WNT3A (0.80) WNT3A
SCHEMBL17108179 0.86 WNT3A (0.71) WNT3A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20170114070-A1 INHIBITORS OF THE WNT SIGNALLING PATHWAYS BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2017-04-27 — — US disclosed
EP-3119787-A1 INHIBITORS OF THE WNT SIGNALLING PATHWAYS Bayer Pharma Aktiengesellschaft (DE) 2017-01-25 — — EP disclosed
WO-2015140196-A1 INHIBITORS OF THE WNT SIGNALLING PATHWAYS BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2015-09-24 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170114070-A1 INHIBITORS OF THE WNT SIGNALLING PATHWAYS WNT1, WNT3A, CTNNB1 WNT3A 2/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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