Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.66 |
| ▸ | GAA | P10253 | 2/20 | 0.66 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.62 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22615009 | 0.89 | ALDH1A1 (0.60) | ALDH1A1KDM4EKMT2AGAACYP1A2 | |
| SCHEMBL12294853 | 0.86 | SMN1; SMN2 (0.60) | ALDH1A1KDM4ECYP1A2CYP2C9CYP2C19 | |
| SCHEMBL16797994 | 0.84 | CYP1A2 (0.63) | ALDH1A1KDM4EKMT2ACYP1A2CYP2C9 | |
| SCHEMBL19723739 | 0.83 | SMN1; SMN2 (0.57) | ALDH1A1KDM4EKMT2AGAACYP1A2 | |
| SCHEMBL6409798 | 0.83 | CYP1A2 (0.66) | ALDH1A1KDM4EKMT2ACYP1A2CYP2C9 | |
| SCHEMBL19723542 | 0.81 | RAB9A (0.56) | ALDH1A1KDM4EKMT2AGAACYP1A2 | |
| SCHEMBL13312213 | 0.81 | CYP1A2 (0.67) | ALDH1A1KDM4EKMT2ACYP1A2CYP2C9 | |
| SCHEMBL27465082 | 0.80 | CYP1A2 (0.70) | ALDH1A1KDM4ECYP1A2CYP2C9CYP2C19 | |
| SCHEMBL11253412 | 0.79 | CYP1A2 (0.65) | ALDH1A1KDM4EKMT2ACYP1A2CYP2C9 | |
| SCHEMBL4343195 | 0.79 | KDM4E (1.00) | ALDH1A1KDM4EKMT2AGAASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3119778-A1 | SUBSTITUTED IMIDAZO[1,2-A]PYRIDINECARBOXAMIDES AND THEIR USE | Bayer Pharma Aktiengesellschaft (DE) | 2017-01-25 | — | — | EP | disclosed |
| WO-2015140254-A1 | SUBSTITUTED IMIDAZO[1,2-A]PYRIDINECARBOXAMIDES AND THEIR USE | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2015-09-24 | — | — | WO | disclosed |