Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | NOTUM | Q6P988 | 6/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 2/20 | 0.34 |
| ▸ | MGLL | Q99685 | 1/20 | 0.34 |
| ▸ | DRD1 | P21728 | 1/20 | 0.34 |
| ▸ | DRD4 | P21917 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8022600 | 0.90 | MEN1 (0.46) | MEN1KMT2AALDH1A1LMNAKDM4E | |
| SCHEMBL5809369 | 0.78 | POLB (0.48) | MEN1KMT2AALDH1A1LMNAHTT | |
| SCHEMBL15651758 | 0.77 | NOTUM (0.65) | NOTUM | |
| SCHEMBL25124854 | 0.74 | ADRB1 (0.33) | KDM4ETSHRDRD2MGLLDRD3 | |
| SCHEMBL24873677 | 0.74 | NOTUM (0.38) | ALDH1A1KDM4EGAAMAPTHPGD | |
| SCHEMBL256749 | 0.73 | NOTUM (0.56) | ALDH1A1KDM4EGAAMAPTHPGD | |
| SCHEMBL13462411 | 0.73 | S1PR1 (0.37) | ALDH1A1KDM4EGAAMAPTHPGD | |
| SCHEMBL14507205 | 0.73 | HTR2A (0.46) | MEN1KMT2ALMNAMAPTNOTUM | |
| SCHEMBL13113610 | 0.72 | NOTUM (0.40) | MEN1KMT2ALMNAKDM4EPABPC1 | |
| SCHEMBL30609086 | 0.72 | NOTUM (0.40) | MEN1KMT2ALMNAKDM4EPABPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012047702-A1 | DIHYDROBENZOQUINAZOLINONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME CORP. (US) | 2012-04-12 | — | — | WO | disclosed |