Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 3/20 | 0.62 |
| ▸ | CCNK | O75909 | 8/20 | 0.41 |
| ▸ | CDK12 | Q9NYV4 | 8/20 | 0.41 |
| ▸ | PIM1 | P11309 | 2/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.41 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21047804 | 0.79 | KDM4E (0.62) | MAPK1HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL31619957 | 0.76 | MAPK1 (0.64) | MAPK1HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL29730384 | 0.76 | MAPK1 (1.00) | MAPK1PIM1HDAC3HDAC1HDAC2 | |
| SCHEMBL26676635 | 0.74 | PIK3CA (0.41) | MAPK1PIM1 | |
| SCHEMBL22570020 | 0.72 | MAPK1 (0.58) | MAPK1CCNKCDK12PIM1HDAC3 | |
| SCHEMBL29138593 | 0.72 | ESR2 (0.37) | MAPK1PIM1 | |
| SCHEMBL28282290 | 0.71 | CCNA2 (0.46) | CCNKCDK12 | |
| SCHEMBL29754817 | 0.71 | IKBKB (0.59) | MAPK1 | |
| SCHEMBL31334769 | 0.71 | MAPK1 (0.53) | MAPK1CCNKCDK12 | |
| SCHEMBL26676723 | 0.70 | HSD11B1 (0.45) | MAPK1PIM1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10301309-B2 | Azaindole acetic acid derivatives and their use as prostaglandin D2 receptor modulators | IDORSIA PHARMACEUTICALS LTD (CH) | 2019-05-28 | — | — | US | disclosed |
| EP-3119779-B1 | AZAINDOLE ACETIC ACID DERIVATIVES AND THEIR USE AS PROSTAGLANDIN D2 RECEPTOR MODULATORS | IDORSIA PHARMACEUTICALS LTD (CH) | 2018-07-11 | — | — | EP | disclosed |
| US-20180105520-A1 | AZAINDOLE ACETIC ACID DERIVATIVES AND THEIR USE AS PROSTAGLANDIN D2 RECEPTOR MODULATORS | ACTELION PHARMACEUTICALS LTD (CH) | 2018-04-19 | — | — | US | disclosed |
| US-9879006-B2 | Azaindole acetic acid derivatives and their use as prostaglandin D2 receptor modulators | IDORSIA PHARMACEUTICALS LTD | 2018-01-30 | — | — | US | disclosed |
| US-20170022196-A1 | AZAINDOLE ACETIC ACID DERIVATIVES AND THEIR USE AS PROSTAGLANDIN D2 RECEPTOR MODULATORS | IDORSIA PHARMACEUTICALS LTD (CH) | 2017-01-26 | — | — | US | disclosed |
| EP-3119779-A1 | AZAINDOLE ACETIC ACID DERIVATIVES AND THEIR USE AS PROSTAGLANDIN D2 RECEPTOR MODULATORS | Actelion Pharmaceuticals Ltd (CH) | 2017-01-25 | — | — | EP | disclosed |
| WO-2015140684-A1 | AZAINDOLE ACETIC ACID DERIVATIVES AND THEIR USE AS PROSTAGLANDIN D2 RECEPTOR MODULATORS | ACTELION PHARMACEUTICALS LTD (CH) | 2015-09-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170022196-A1 | AZAINDOLE ACETIC ACID DERIVATIVES AND THEIR USE AS PROSTAGLANDIN D2 RECEPTOR MODULATORS | PTGDR, PTGDR2, PTGER2 | MAPK1 1256/4885CCNK 1638/4885CDK12 891/4885 |
| US-10301309-B2 | Azaindole acetic acid derivatives and their use as prostaglandin D2 receptor modulators | PTGDR, PTGDR2, PTGER2 | MAPK1 1256/4885CCNK 1638/4885CDK12 891/4885 |
| US-20180105520-A1 | AZAINDOLE ACETIC ACID DERIVATIVES AND THEIR USE AS PROSTAGLANDIN D2 RECEPTOR MODULATORS | PTGDR, PTGDR2, PTGER2 | MAPK1 1256/4885CCNK 1638/4885CDK12 891/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.