Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | PPIA | P62937 | 2/20 | 0.34 |
| ▸ | USP2 | O75604 | 2/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | BTK | Q06187 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | CTSK | P43235 | 4/20 | 0.32 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.31 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.31 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15913346 | 0.84 | CA1 (0.35) | CA1CA2PPIAEPHX2HPGD | |
| SCHEMBL30069367 | 0.81 | CA1 (0.33) | CA1CA2PPIAEPHX2HPGD | |
| SCHEMBL22981385 | 0.78 | CTSK (0.32) | CA1CA2PPIACTSK | |
| SCHEMBL22981386 | 0.78 | CTSK (0.32) | CA1CA2PPIACTSK | |
| SCHEMBL13737672 | 0.78 | EPHX2 (0.36) | USP2EPHX2MEN1MAPK1KMT2A | |
| SCHEMBL3295187 | 0.78 | EPHX2 (0.36) | USP2EPHX2MEN1MAPK1KMT2A | |
| SCHEMBL27947023 | 0.78 | EPHX2 (0.36) | USP2EPHX2MEN1MAPK1KMT2A | |
| SCHEMBL23802954 | 0.77 | CTSK (0.33) | CA1CA2HPGDCTSK | |
| SCHEMBL23802991 | 0.77 | CTSK (0.33) | CA1CA2HPGDCTSK | |
| SCHEMBL23802952 | 0.77 | CTSK (0.33) | CA1CA2HPGDCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2344473-A1 | HETEROCYCLIC PIM-KINASE INHIBITORS | Novartis AG (CH) | 2011-07-20 | — | — | EP | disclosed |
| WO-2010026122-A1 | HETEROCYCLIC PIM-KINASE INHIBITORS | NOVARTIS AG (CH) | 2010-03-11 | — | — | WO | disclosed |