Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 3/20 | 0.50 |
| ▸ | CES1 | P23141 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MDM2 | Q00987 | 4/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.35 |
| ▸ | GABRP | O00591 | 1/20 | 0.34 |
| ▸ | GABRD | O14764 | 1/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.34 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.34 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.34 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.34 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.34 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.34 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.34 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.34 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.34 |
| ▸ | GABRE | P78334 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13817452 | 0.76 | NPC1 (0.50) | CES2CES1MAPTMEN1HPGD | |
| SCHEMBL17219570 | 0.75 | CES2 (0.55) | CES2CES1ALDH1A1MDM2KEAP1 | |
| SCHEMBL21509855 | 0.73 | CES2 (0.63) | CES2CES1ALDH1A1MDM2MAPT | |
| SCHEMBL27764538 | 0.73 | CES2 (0.63) | CES2CES1ALDH1A1MDM2MAPT | |
| SCHEMBL2099037 | 0.72 | CES2 (0.61) | CES2CES1ALDH1A1MDM2MAPT | |
| SCHEMBL954719 | 0.72 | CES2 (0.61) | CES2CES1ALDH1A1MDM2MAPT | |
| SCHEMBL31130589 | 0.72 | CES2 (0.61) | CES2CES1ALDH1A1MDM2MAPT | |
| SCHEMBL15435529 | 0.72 | CES2 (0.61) | CES2CES1ALDH1A1MDM2MAPT | |
| SCHEMBL29798926 | 0.72 | CES2 (0.61) | CES2CES1ALDH1A1MDM2MAPT | |
| SCHEMBL3094911 | 0.72 | CES2 (0.61) | CES2CES1ALDH1A1MDM2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9481680-B2 | Process for the preparation of key intermediates of omarigliptin | F.I.S.—FABBRICA ITALIANA SINTETICI S.P.A (IT) | 2016-11-01 | — | — | US | disclosed |
| US-9481680-B2 | Process for the preparation of key intermediates of omarigliptin | F.I.S.—FABBRICA ITALIANA SINTETICI S.P.A (IT) | 2016-11-01 | — | — | US | disclosed |
| US-9481680-B2 | Process for the preparation of key intermediates of omarigliptin | F.I.S.—FABBRICA ITALIANA SINTETICI S.P.A (IT) | 2016-11-01 | — | — | US | disclosed |
| US-20160200727-A1 | PROCESS FOR THE PREPARATION OF KEY INTERMEDIATES OF OMARIGLIPTIN | F.I.S.- FABBRICA ITALIANA SINTETICI S.P.A. (IT) | 2016-07-14 | — | — | US | disclosed |
| US-20160200727-A1 | PROCESS FOR THE PREPARATION OF KEY INTERMEDIATES OF OMARIGLIPTIN | F.I.S.- FABBRICA ITALIANA SINTETICI S.P.A. (IT) | 2016-07-14 | — | — | US | disclosed |
| US-20160200727-A1 | PROCESS FOR THE PREPARATION OF KEY INTERMEDIATES OF OMARIGLIPTIN | F.I.S.- FABBRICA ITALIANA SINTETICI S.P.A. (IT) | 2016-07-14 | — | — | US | disclosed |
| EP-2997008-B1 | PROCESS FOR THE PREPARATION OF KEY INTERMEDIATES OF OMARIGLIPTIN | ITALIANA SINT SPA (IT) | 2016-06-29 | — | — | EP | disclosed |
| EP-2997008-B1 | PROCESS FOR THE PREPARATION OF KEY INTERMEDIATES OF OMARIGLIPTIN | ITALIANA SINT SPA (IT) | 2016-06-29 | — | — | EP | disclosed |
| EP-2997008-A1 | PROCESS FOR THE PREPARATION OF KEY INTERMEDIATES OF OMARIGLIPTIN | F.I.S.- Fabbrica Italiana Sintetici S.p.A. (IT) | 2016-03-23 | — | — | EP | disclosed |
| WO-2015139859-A1 | PROCESS FOR THE PREPARATION OF KEY INTERMEDIATES OF OMARIGLIPTIN | F.I.S. - FABBRICA ITALIANA SINTETICI S.P.A. (IT) | 2015-09-24 | — | — | WO | disclosed |
| WO-2015139859-A1 | PROCESS FOR THE PREPARATION OF KEY INTERMEDIATES OF OMARIGLIPTIN | F.I.S. - FABBRICA ITALIANA SINTETICI S.P.A. (IT) | 2015-09-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160200727-A1 | PROCESS FOR THE PREPARATION OF KEY INTERMEDIATES OF OMARIGLIPTIN | SI, OSTC, VIP | CES2 3492/4885CES1 811/4885ALDH1A1 3011/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.