Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 13/20 | 0.42 |
| ▸ | HTR2A | P28223 | 3/20 | 0.42 |
| ▸ | HTR7 | P34969 | 3/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | CTSL | P07711 | 1/20 | 0.35 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.35 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.35 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 2/20 | 0.35 |
| ▸ | MAP3K8 | P41279 | 1/20 | 0.34 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.34 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.34 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.34 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.34 |
| ▸ | VSIR | Q9H7M9 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17097269 | 0.94 | HTR6 (0.42) | HTR6HTR2AHTR7CA12CA1 | |
| SCHEMBL17097177 | 0.86 | HTR6 (0.42) | HTR6HTR2AHTR7CA12CA1 | |
| SCHEMBL17097305 | 0.84 | KDM4E (0.45) | HTR6HTR2AHTR7CA12CA1 | |
| SCHEMBL17102146 | 0.84 | IDO1 (0.43) | HTR6HTR2AHTR7CA12CA1 | |
| SCHEMBL17097217 | 0.83 | HTR6 (0.42) | HTR6HTR2AHTR7CA12CA1 | |
| SCHEMBL17096725 | 0.83 | HTR6 (0.43) | HTR6HTR2AHTR7CA12CA1 | |
| SCHEMBL17610358 | 0.82 | HTR6 (0.43) | HTR6HTR2AHTR7CA12CA1 | |
| SCHEMBL17097082 | 0.82 | HTR6 (0.46) | HTR6HTR2AHTR7CA12CA1 | |
| SCHEMBL17097280 | 0.82 | HTR6 (0.41) | HTR6HTR2AHTR7CA12CA1 | |
| SCHEMBL17097068 | 0.81 | HTR6 (0.47) | HTR6HTR2AHTR7CA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3119763-A1 | NOVEL 3-INDOL SUBSTITUTED DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND METHODS FOR USE | Iteos Therapeutics (BE) | 2017-01-25 | — | — | EP | disclosed |
| WO-2015140717-A1 | NOVEL 3-INDOL SUBSTITUTED DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND METHODS FOR USE | ITEOS THERAPEUTICS (BE) | 2015-09-24 | — | — | WO | disclosed |