Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 13/20 | 0.43 |
| ▸ | HTR2A | P28223 | 4/20 | 0.43 |
| ▸ | HTR7 | P34969 | 3/20 | 0.43 |
| ▸ | DRD2 | P14416 | 3/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | TNFSF11 | O14788 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | TNF | P01375 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17097098 | 0.90 | CACNA1G (0.40) | HTR6HTR2AHTR7DRD2RXFP1 | |
| SCHEMBL17097305 | 0.86 | KDM4E (0.45) | HTR6HTR2AHTR7DRD2CA12 | |
| SCHEMBL17097177 | 0.86 | HTR6 (0.42) | HTR6HTR2AHTR7DRD2CA12 | |
| SCHEMBL17097236 | 0.85 | HTR6 (0.42) | HTR6HTR2AHTR7DRD2CA12 | |
| SCHEMBL17097217 | 0.85 | HTR6 (0.42) | HTR6HTR2AHTR7DRD2CA12 | |
| SCHEMBL17096725 | 0.84 | HTR6 (0.43) | HTR6HTR2AHTR7DRD2CA12 | |
| SCHEMBL17102146 | 0.84 | IDO1 (0.43) | HTR6HTR2AHTR7DRD2CA12 | |
| SCHEMBL17097280 | 0.84 | HTR6 (0.41) | HTR6HTR2AHTR7DRD2CA12 | |
| SCHEMBL17097250 | 0.83 | HTR6 (0.42) | HTR6HTR2AHTR7DRD2CA12 | |
| SCHEMBL17097068 | 0.83 | HTR6 (0.47) | HTR6HTR2AHTR7DRD2CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015140717-A9 | NOVEL 3-INDOL SUBSTITUTED DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND METHODS FOR USE | ITEOS THERAPEUTICS (BE) | 2016-03-24 | — | — | WO | disclosed |