Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.33 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.33 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.33 |
| ▸ | P2RX3 | P56373 | 7/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.32 |
| ▸ | SELE | P16581 | 1/20 | 0.32 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.31 |
| ▸ | EP300 | Q09472 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1710209 | 0.90 | KDM4C (0.33) | KDM4CNPC1RAB9AL3MBTL1P2RX3 | |
| SCHEMBL1710294 | 0.87 | KDM4C (0.40) | KDM4CNPC1RAB9AL3MBTL1CCNA2 | |
| SCHEMBL1710182 | 0.85 | NPC1 (0.38) | KDM4CNPC1RAB9AL3MBTL1CCNA2 | |
| SCHEMBL1710200 | 0.85 | NPC1 (0.41) | KDM4CNPC1RAB9AL3MBTL1CCNA2 | |
| SCHEMBL1562973 | 0.84 | KDM4C (0.35) | KDM4CNPC1RAB9AL3MBTL1CCNA2 | |
| SCHEMBL3125092 | 0.79 | NPC1 (0.36) | KDM4CNPC1RAB9AL3MBTL1CCNA2 | |
| SCHEMBL1710342 | 0.78 | NPC1 (0.33) | KDM4CNPC1RAB9A | |
| SCHEMBL1710212 | 0.77 | NPC1 (0.36) | KDM4CNPC1RAB9AL3MBTL1CCNA2 | |
| SCHEMBL3125095 | 0.77 | NPC1 (0.34) | KDM4CNPC1RAB9ACCNA2CDK2 | |
| SCHEMBL5522712 | 0.76 | KDM4C (0.37) | KDM4CNPC1RAB9AL3MBTL1P2RX3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2344477-A1 | SMALL MOLECULE BRADYKININ B2 RECEPTOR MODULATORS | Jerini AG (DE) | 2011-07-20 | — | — | EP | disclosed |
| WO-2010031589-A1 | SMALL MOLECULE BRADYKININ B2 RECEPTOR MODULATORS | JERINI AG (DE) | 2010-03-25 | — | — | WO | disclosed |