SCHEMBL1710485

SCHEMBL1710485

CCCc1cccc(SCCc2ccccc2)c1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.51
CYP3A4 P08684 1/20 0.51
CYP2D6 P10635 1/20 0.51
CYP2C9 P11712 1/20 0.51
CYP2C19 P33261 1/20 0.51
HIF1A Q16665 1/20 0.51
MAOA P21397 4/20 0.50
MAOB P27338 4/20 0.50
KIF11 P52732 1/20 0.47
HTR2C P28335 1/20 0.46
HTR6 P50406 1/20 0.46
MCL1 Q07820 2/20 0.45
BCL2A1 Q16548 2/20 0.45
ALDH1A1 P00352 1/20 0.43
MAPK1 P28482 1/20 0.43
HDAC1 Q13547 1/20 0.43
CA12 O43570 1/20 0.42
CA1 P00915 1/20 0.42
CA2 P00918 1/20 0.42
CA7 P43166 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1710819 0.86 MAOA (0.46) CYP1A2CYP3A4CYP2D6CYP2C9CYP2C19
Fluoride SCHEMBL9841585 0.85 CYP1A2 (0.59) CYP1A2CYP3A4CYP2D6CYP2C9CYP2C19
SCHEMBL21531822 0.83 HTR2C (0.42) MAOAKIF11HTR2CHTR6DRD2
SCHEMBL1710556 0.79 HTR6 (0.56) CYP1A2CYP3A4CYP2D6CYP2C9CYP2C19
SCHEMBL13459322 0.79 MEN1 (0.62) CYP1A2CYP3A4CYP2D6CYP2C9CYP2C19
SCHEMBL9189880 0.79 HTR2C (0.44) CYP1A2CYP2C9KIF11HTR2CHTR6
SCHEMBL25382633 0.78 MAOA (0.56) MAOAMAOBKIF11ALDH1A1DRD2
SCHEMBL223719 0.78 CYP1A2 (0.76) CYP1A2CYP3A4CYP2D6CYP2C9CYP2C19
SCHEMBL10061751 0.77 HTR2C (0.43) KIF11HTR2CHTR6DRD2DRD3
SCHEMBL1710624 0.76 CYP1A2 (0.53) CYP1A2CYP3A4CYP2D6CYP2C9CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2344451-A2 SULFUR-LINKED COMPOUNDS FOR TREATING OPTHALMIC DISEASES AND DISORDERS Acucela, Inc. (US) 2011-07-20 EP disclosed
WO-2010028088-A2 SULFUR-LINKED COMPOUNDS FOR TREATING OPTHALMIC DISEASES AND DISORDERS ACUCELA, INC. (US) 2010-03-11 WO disclosed