Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSD | P07339 | 3/20 | 0.54 |
| ▸ | PSMB1 | P20618 | 2/20 | 0.49 |
| ▸ | F2 | P00734 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | CTSL | P07711 | 3/20 | 0.45 |
| ▸ | CTSS | P25774 | 3/20 | 0.45 |
| ▸ | CTSK | P43235 | 2/20 | 0.45 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.45 |
| ▸ | PSMB11 | A5LHX3 | 1/20 | 0.44 |
| ▸ | PSMA7 | O14818 | 1/20 | 0.44 |
| ▸ | PSMA1 | P25786 | 1/20 | 0.44 |
| ▸ | PSMA2 | P25787 | 1/20 | 0.44 |
| ▸ | PSMA3 | P25788 | 1/20 | 0.44 |
| ▸ | PSMA4 | P25789 | 1/20 | 0.44 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.44 |
| ▸ | PSMB9 | P28065 | 1/20 | 0.44 |
| ▸ | PSMA5 | P28066 | 1/20 | 0.44 |
| ▸ | PSMB4 | P28070 | 1/20 | 0.44 |
| ▸ | PSMB6 | P28072 | 1/20 | 0.44 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17106927 | 1.00 | CTSD (0.54) | CTSDPSMB1F2HDAC8CTSL | |
| SCHEMBL17106928 | 1.00 | CTSD (0.54) | CTSDPSMB1F2HDAC8CTSL | |
| SCHEMBL17106914 | 0.87 | CAPN1 (0.51) | CTSDF2HDAC8CTSLCTSS | |
| SCHEMBL17107010 | 0.85 | CTSD (0.61) | CTSDPSMB1F2HDAC8CTSL | |
| SCHEMBL17107006 | 0.85 | CTSD (0.61) | CTSDPSMB1F2HDAC8CTSL | |
| SCHEMBL17107007 | 0.85 | CTSD (0.61) | CTSDPSMB1F2HDAC8CTSL | |
| SCHEMBL17107009 | 0.85 | CTSD (0.61) | CTSDPSMB1F2HDAC8CTSL | |
| SCHEMBL16464284 | 0.84 | CYP3A4 (0.56) | F2HDAC8CTSLCTSSCTSK | |
| SCHEMBL17106926 | 0.84 | CYP3A4 (0.56) | F2HDAC8CTSLCTSSCTSK | |
| SCHEMBL17107003 | 0.84 | KLKB1 (0.52) | CTSDKLKB1ATMTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150274777-A1 | KETOAMIDE IMMUNOPROTEASOME INHIBITORS | HOFFMANN-LA ROCHE INC. | 2015-10-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150274777-A1 | KETOAMIDE IMMUNOPROTEASOME INHIBITORS | PSMB7, PSMB5, PSMC2 | CTSD 341/4885PSMB1 7/4885F2 2101/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.