Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1B | Q00975 | 2/20 | 0.50 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.48 |
| ▸ | YAP1 | P46937 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | CTSL | P07711 | 1/20 | 0.44 |
| ▸ | CTSS | P25774 | 1/20 | 0.44 |
| ▸ | CTSK | P43235 | 1/20 | 0.44 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.44 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16462455 | 1.00 | CACNA1B (0.50) | CACNA1BKLK5YAP1MAPTCYP3A4 | |
| SCHEMBL16464284 | 0.88 | CYP3A4 (0.56) | MAPTCYP3A4TSHRALDH1A1MEN1 | |
| SCHEMBL17106926 | 0.88 | CYP3A4 (0.56) | MAPTCYP3A4TSHRALDH1A1MEN1 | |
| SCHEMBL9240969 | 0.87 | CACNA1B (0.60) | CACNA1BKLK5HDAC8ATMCTSL | |
| SCHEMBL6438287 | 0.87 | CACNA1B (0.60) | CACNA1BKLK5HDAC8ATMCTSL | |
| SCHEMBL7292396 | 0.87 | CACNA1B (0.60) | CACNA1BKLK5HDAC8ATMCTSL | |
| SCHEMBL17106905 | 0.85 | ATM (0.54) | MAPTCYP3A4TSHRALDH1A1MEN1 | |
| SCHEMBL16463321 | 0.85 | ATM (0.54) | MAPTCYP3A4TSHRALDH1A1MEN1 | |
| SCHEMBL8063643 | 0.85 | HTRA1 (0.46) | CACNA1BKLK5ALDH1A1CTSLCTSS | |
| SCHEMBL15654438 | 0.84 | KLK5 (0.53) | CACNA1BKLK5MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150274777-A1 | KETOAMIDE IMMUNOPROTEASOME INHIBITORS | HOFFMANN-LA ROCHE INC. | 2015-10-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150274777-A1 | KETOAMIDE IMMUNOPROTEASOME INHIBITORS | PSMB7, PSMB5, PSMC2 | CACNA1B 2869/4885KLK5 154/4885YAP1 4818/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.