Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTRA1 | Q92743 | 1/20 | 0.46 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.45 |
| ▸ | MMP1 | P03956 | 4/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | PPARA | Q07869 | 1/20 | 0.43 |
| ▸ | FAAH | O00519 | 1/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.41 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.39 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.39 |
| ▸ | CTSL | P07711 | 1/20 | 0.39 |
| ▸ | CTSB | P07858 | 1/20 | 0.39 |
| ▸ | CTSS | P25774 | 1/20 | 0.39 |
| ▸ | CTSK | P43235 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.39 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7229743 | 0.90 | CTSS (0.47) | KLK5CTSSCTSK | |
| SCHEMBL7221973 | 0.87 | HTRA1 (0.40) | HTRA1KLK5ITGB3ITGA2BCTSL | |
| SCHEMBL8067917 | 0.85 | NPSR1 (0.54) | KLK5ALDH1A1CTSSCTSK | |
| SCHEMBL16462455 | 0.85 | CACNA1B (0.50) | CACNA1BKLK5ALDH1A1ITGB3ITGA2B | |
| SCHEMBL17106960 | 0.85 | CACNA1B (0.50) | CACNA1BKLK5ALDH1A1ITGB3ITGA2B | |
| SCHEMBL3149446 | 0.84 | PPARG (0.54) | CACNA1BPPARGPPARAKLK5ALDH1A1 | |
| SCHEMBL31461540 | 0.84 | PPARG (0.44) | HTRA1CACNA1BMMP1PPARGPPARA | |
| SCHEMBL7223168 | 0.84 | KLK5 (0.45) | KLK5ALDH1A1CTSLCTSBCTSS | |
| SCHEMBL7229912 | 0.83 | HDAC1 (0.47) | CTSSCTSK | |
| SCHEMBL6376830 | 0.83 | ECE1 (0.42) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0655461-B1 | Cyclic amino acid derivatives having ACE and NEP inhibiting activity | NOVARTIS AG (CH) | 2000-06-07 | — | — | EP | disclosed |
| US-5668158-A | TREATMENT OF CARDIOVASCULAR DISORDERS | NOVARTIS CORPORATION (US) | 1997-09-16 | — | — | US | disclosed |
| US-5506244-A | TREATING CARDIOVASCULAR DISORDERS | CIBA-GEIGY CORPORATION (US) | 1996-04-09 | — | — | US | disclosed |
| EP-0655461-A1 | Cyclic amino acid derivatives having ACE and NEP inhibiting activity | CIBA-GEIGY AG (CH) | 1995-05-31 | — | — | EP | disclosed |