Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 3/20 | 0.40 |
| ▸ | CA1 | P00915 | 3/20 | 0.40 |
| ▸ | CA2 | P00918 | 3/20 | 0.40 |
| ▸ | CA9 | Q16790 | 3/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | IL1RN | P18510 | 1/20 | 0.34 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3385727 | 0.84 | HSD11B1 (0.38) | CA12CA1CA2CA9HSD11B1 | |
| SCHEMBL3388612 | 0.84 | CA1 (0.43) | CA12CA1CA2CA9GAA | |
| SCHEMBL1727476 | 0.84 | CA1 (0.42) | CA12CA1CA2CA9TDP1 | |
| SCHEMBL1725084 | 0.83 | GAA (0.38) | CA12CA1CA2CA9HSD11B1 | |
| SCHEMBL2151202 | 0.77 | CA12 (0.41) | CA12CA1CA2CA9NPSR1 | |
| SCHEMBL1726349 | 0.76 | ALDH1A1 (0.38) | NPSR1TDP1GAAPOLBHSD17B10 | |
| SCHEMBL2150646 | 0.76 | CA12 (0.40) | CA12CA1CA2CA9ALDH1A1 | |
| SCHEMBL3969117 | 0.75 | TP53 (0.43) | GAAALDH1A1 | |
| SCHEMBL16031782 | 0.75 | APEX1 (0.39) | CA12CA1CA2CA9HSD11B1 | |
| SCHEMBL16031780 | 0.75 | HSD11B1 (0.38) | CA12CA1CA2CA9HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2344451-A2 | SULFUR-LINKED COMPOUNDS FOR TREATING OPTHALMIC DISEASES AND DISORDERS | Acucela, Inc. (US) | 2011-07-20 | — | — | EP | disclosed |
| WO-2010028088-A2 | SULFUR-LINKED COMPOUNDS FOR TREATING OPTHALMIC DISEASES AND DISORDERS | ACUCELA, INC. (US) | 2010-03-11 | — | — | WO | disclosed |