Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 1/20 | 0.69 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.43 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.37 |
| ▸ | IRAK4 | Q9NWZ3 | 5/20 | 0.36 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | IDH1 | O75874 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | IDH2 | P48735 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17110907 | 1.00 | TRPA1 (0.69) | TRPA1HSD11B1ANO1IRAK4GRM4 | |
| SCHEMBL17112664 | 1.00 | TRPA1 (0.69) | TRPA1HSD11B1ANO1IRAK4GRM4 | |
| SCHEMBL15638403 | 0.94 | TRPA1 (0.66) | TRPA1HSD11B1ANO1POLBL3MBTL1 | |
| SCHEMBL17112686 | 0.94 | TRPA1 (0.66) | TRPA1HSD11B1ANO1POLBL3MBTL1 | |
| SCHEMBL17112650 | 0.94 | TRPA1 (0.66) | TRPA1HSD11B1ANO1POLBL3MBTL1 | |
| SCHEMBL17110984 | 0.84 | TRPA1 (0.49) | TRPA1ANO1IRAK4POLBL3MBTL1 | |
| SCHEMBL17110894 | 0.84 | TRPA1 (0.49) | TRPA1ANO1IRAK4POLBL3MBTL1 | |
| SCHEMBL17110897 | 0.84 | TRPA1 (0.49) | TRPA1ANO1IRAK4POLBL3MBTL1 | |
| SCHEMBL17110970 | 0.84 | TRPA1 (0.61) | TRPA1HSD11B1GRM4POLBL3MBTL1 | |
| SCHEMBL15635661 | 0.82 | TRPA1 (0.62) | TRPA1HSD11B1ANO1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015144977-A1 | TRPA1 MODULATORS | ORIEN CORPORATION (FI) | 2015-10-01 | — | — | WO | disclosed |
| WO-2015144976-A1 | TRPA1 MODULATORS | ORION CORPORATION (FI) | 2015-10-01 | — | — | WO | disclosed |