Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 2/20 | 0.39 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.36 |
| ▸ | KDM5A | P29375 | 1/20 | 0.36 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.36 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | CETP | P11597 | 2/20 | 0.35 |
| ▸ | IDH1 | O75874 | 4/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | IDH2 | P48735 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17110968 | 0.92 | MAPK8 (0.43) | MAPK8IRAK4KDM5AKDM4CKDM5B | |
| SCHEMBL15636753 | 0.90 | TRPA1 (0.39) | MAPK8IRAK4HCAR3 | |
| SCHEMBL15635529 | 0.81 | JAK2 (0.46) | MAPK8HCAR3 | |
| SCHEMBL871750 | 0.81 | JAK2 (0.46) | HCAR3 | |
| SCHEMBL17110980 | 0.80 | TRPA1 (0.45) | MAPK8IRAK4MAPK1IDH1 | |
| SCHEMBL17110967 | 0.79 | TRPA1 (0.49) | IDH1 | |
| Niacinamide SCHEMBL17110973 | 0.78 | GBA1 (0.44) | MAPK8KDM5AKDM4CKDM5BDYRK1A | |
| SCHEMBL4100544 | 0.78 | HCAR3 (0.38) | IRAK4HCAR3 | |
| SCHEMBL17110894 | 0.77 | TRPA1 (0.49) | MAPK8IRAK4CETP | |
| SCHEMBL17110984 | 0.77 | TRPA1 (0.49) | MAPK8IRAK4CETP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015144977-A1 | TRPA1 MODULATORS | ORIEN CORPORATION (FI) | 2015-10-01 | — | — | WO | disclosed |