Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 6/20 | 0.45 |
| ▸ | METTL3 | Q86U44 | 10/20 | 0.45 |
| ▸ | ADK | P55263 | 5/20 | 0.42 |
| ▸ | RAPGEF3 | O95398 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17106864 | 0.96 | PRMT5 (0.47) | PRMT5METTL3ADKRAPGEF3 | |
| SCHEMBL17106848 | 0.88 | METTL3 (0.47) | PRMT5METTL3ADK | |
| SCHEMBL17111262 | 0.88 | METTL3 (0.47) | PRMT5METTL3ADK | |
| SCHEMBL17111234 | 0.88 | METTL3 (0.47) | PRMT5METTL3ADK | |
| SCHEMBL17106763 | 0.87 | ADK (0.41) | PRMT5METTL3ADK | |
| SCHEMBL17106819 | 0.87 | PRMT5 (0.48) | PRMT5METTL3ADKRAPGEF3 | |
| SCHEMBL17111225 | 0.86 | ADK (0.47) | PRMT5METTL3ADK | |
| SCHEMBL17111224 | 0.86 | ADK (0.47) | PRMT5METTL3ADK | |
| SCHEMBL17106786 | 0.86 | ADK (0.47) | PRMT5METTL3ADK | |
| SCHEMBL17106721 | 0.86 | PRMT5 (0.38) | PRMT5METTL3ADK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015143712-A1 | 4'-SUBSTITUTED NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2015-10-01 | — | — | WO | disclosed |