Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | PARP1 | P09874 | 2/20 | 0.52 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.52 |
| ▸ | PARP3 | Q9Y6F1 | 2/20 | 0.52 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.51 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.50 |
| ▸ | NAMPT | P43490 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | JAK1 | P23458 | 1/20 | 0.42 |
| ▸ | TYK2 | P29597 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20765774 | 0.82 | PARP1 (0.52) | MAPTMEN1NPC1LMNARAB9A | |
| SCHEMBL29633279 | 0.81 | ADORA3 (0.42) | KMT2APARP1FGFR1ALDH1A1JAK2 | |
| SCHEMBL15910787 | 0.76 | MAPT (0.57) | MAPTMEN1NPC1LMNARAB9A | |
| SCHEMBL3715135 | 0.76 | CHEK2 (0.43) | PARP1PARP2FGFR1ALDH1A1JAK2 | |
| SCHEMBL9989118 | 0.75 | KDM4E (0.57) | MAPTKMT2ASMN1; SMN2ALDH1A1JAK2 | |
| SCHEMBL9989115 | 0.75 | MKNK1 (0.42) | MAPTKMT2ASMN1; SMN2ALDH1A1JAK2 | |
| SCHEMBL19328774 | 0.74 | MKNK1 (0.46) | PARP1PARP2PARP3ESR2ALDH1A1 | |
| SCHEMBL29564697 | 0.74 | MKNK1 (0.46) | PARP1PARP2PARP3ESR2ALDH1A1 | |
| SCHEMBL3668881 | 0.74 | ESR2 (0.50) | MAPTMEN1NPC1LMNARAB9A | |
| SCHEMBL31311094 | 0.73 | PLA2G10 (0.50) | MAPTMEN1NPC1LMNARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3122344-A2 | TrkA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF | Merck Sharp & Dohme Corp. (US) | 2017-02-01 | — | — | EP | claimed |
| WO-2015148354-A2 | TrkA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF | MERCK SHARP & DOHME CORP. (US) | 2015-10-01 | — | — | WO | claimed |