Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 7/20 | 0.43 |
| ▸ | PARP10 | Q53GL7 | 3/20 | 0.43 |
| ▸ | PLAU | P00749 | 1/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 3/20 | 0.40 |
| ▸ | JAK1 | P23458 | 3/20 | 0.40 |
| ▸ | TYK2 | P29597 | 3/20 | 0.40 |
| ▸ | JAK3 | P52333 | 3/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | TNKS | O95271 | 1/20 | 0.39 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.39 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.39 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.39 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17112018 | 0.76 | MAPT (0.55) | CHEK2PLAUFGFR1JAK2JAK1 | |
| SCHEMBL9989118 | 0.72 | KDM4E (0.57) | JAK2JAK1TYK2JAK3LCK | |
| SCHEMBL20214272 | 0.70 | KDM4E (0.46) | ALDH1A1HPGD | |
| SCHEMBL29633279 | 0.69 | ADORA3 (0.42) | CHEK2PARP10FGFR1JAK2JAK1 | |
| SCHEMBL30177194 | 0.69 | HPGDS (0.40) | CHEK2PARP10PLAULCKPARP2 | |
| SCHEMBL29462782 | 0.67 | CES2 (0.68) | CHEK2PLAUJAK1LCKPARP1 | |
| SCHEMBL546633 | 0.67 | CES2 (0.68) | CHEK2PLAUJAK1LCKPARP1 | |
| SCHEMBL26903783 | 0.67 | CES2 (0.68) | CHEK2PLAUJAK1LCKPARP1 | |
| SCHEMBL2363489 | 0.66 | LCK (0.78) | PARP10PLAULCKTNKSPARP15 | |
| SCHEMBL30177171 | 0.66 | KMT2A (0.40) | CHEK2PARP10PLAUFGFR1JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010103438-A1 | SUBSTITUTED INDAZOLE AMIDES AND THEIR USE AS GLUCOKINASE ACTIVATORS | PFIZER INC. (US) | 2010-09-16 | — | — | WO | disclosed |