Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 16/20 | 0.55 |
| ▸ | CHRNA4 | P43681 | 16/20 | 0.55 |
| ▸ | CHRNA3 | P32297 | 15/20 | 0.55 |
| ▸ | CHRNB4 | P30926 | 14/20 | 0.55 |
| ▸ | CHRNA7 | P36544 | 14/20 | 0.55 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.39 |
| ▸ | CHRNA6 | Q15825 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1711187 | 1.00 | CHRNB2 (0.55) | CHRNB2CHRNA4CHRNA3CHRNB4CHRNA7 | |
| SCHEMBL1711516 | 0.89 | CHRNB2 (0.51) | CHRNB2CHRNA4CHRNA3CHRNB4CHRNA7 | |
| SCHEMBL3236313 | 0.86 | CHRNB2 (0.43) | CHRNB2CHRNA4CHRNA3CHRNB4CHRNA7 | |
| SCHEMBL1710950 | 0.85 | CHRNB2 (0.50) | CHRNB2CHRNA4CHRNA3CHRNB4CHRNA7 | |
| SCHEMBL1711203 | 0.85 | CHRNB2 (0.50) | CHRNB2CHRNA4CHRNA3CHRNB4CHRNA7 | |
| SCHEMBL1711262 | 0.83 | CHRNB2 (0.67) | CHRNB2CHRNA4CHRNA3CHRNB4CHRNA7 | |
| SCHEMBL1711284 | 0.83 | CHRNB2 (0.67) | CHRNB2CHRNA4CHRNA3CHRNB4CHRNA7 | |
| SCHEMBL1711502 | 0.83 | CHRNB2 (0.67) | CHRNB2CHRNA4CHRNA3CHRNB4CHRNA7 | |
| SCHEMBL1711422 | 0.80 | CHRNB2 (0.67) | CHRNB2CHRNA4CHRNA3CHRNB4CHRNA7 | |
| SCHEMBL1711178 | 0.79 | CHRNB2 (0.54) | CHRNB2CHRNA4CHRNA3CHRNB4CHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110263629-A1 | AMIDES OF DIAZABICYCLOOCTANES AND USES THEREOF | TARGACEPT, INC. (US) | 2011-10-27 | — | — | US | claimed |
| EP-2344496-A1 | AMIDES OF DIAZABICYCLOOCTANES AND USES THEREOF | Targacept Inc. (US) | 2011-07-20 | — | — | EP | claimed |
| WO-2010028033-A1 | AMIDES OF DIAZABICYCLOOCTANES AND USES THEREOF | TARGACEPT, INC. (US) | 2010-03-11 | — | — | WO | claimed |
| US-20110263629-A1 | AMIDES OF DIAZABICYCLOOCTANES AND USES THEREOF | TARGACEPT, INC. (US) | 2011-10-27 | — | — | US | disclosed |
| US-20110263629-A1 | AMIDES OF DIAZABICYCLOOCTANES AND USES THEREOF | TARGACEPT, INC. (US) | 2011-10-27 | — | — | US | disclosed |
| US-20110263629-A1 | AMIDES OF DIAZABICYCLOOCTANES AND USES THEREOF | TARGACEPT, INC. (US) | 2011-10-27 | — | — | US | disclosed |
| EP-2344496-A1 | AMIDES OF DIAZABICYCLOOCTANES AND USES THEREOF | Targacept Inc. (US) | 2011-07-20 | — | — | EP | disclosed |
| WO-2010028033-A1 | AMIDES OF DIAZABICYCLOOCTANES AND USES THEREOF | TARGACEPT, INC. (US) | 2010-03-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110263629-A1 | AMIDES OF DIAZABICYCLOOCTANES AND USES THEREOF | CHRNA2, CHRNA10, CHRNA5 | CHRNB2 7/4885CHRNA4 5/4885CHRNA3 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.