Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATXN2 | Q99700 | 11/20 | 0.59 |
| ▸ | CNR2 | P34972 | 2/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17112481 | 0.93 | ATXN2 (0.58) | ATXN2CNR2 | |
| SCHEMBL14784457 | 0.86 | CA2 (0.47) | ATXN2CA2 | |
| SCHEMBL17112461 | 0.85 | ATXN2 (0.57) | ATXN2CNR2 | |
| SCHEMBL28737007 | 0.80 | ATXN2 (0.48) | ATXN2CNR2CA2GRM5 | |
| SCHEMBL17112414 | 0.77 | ATXN2 (0.42) | ATXN2CNR2GRM5 | |
| SCHEMBL17112460 | 0.77 | ATXN2 (0.43) | ATXN2 | |
| SCHEMBL29663877 | 0.77 | ATXN2 (0.43) | ATXN2 | |
| SCHEMBL841482 | 0.75 | MAPT (0.44) | ATXN2GRM5 | |
| SCHEMBL21321749 | 0.74 | ATXN2 (0.76) | ATXN2CA2 | |
| SCHEMBL22195255 | 0.74 | ATXN2 (0.81) | ATXN2CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3122750-B1 | BICYCLIC COMPOUNDS AS AUTOTAXIN (ATX) AND LYSOPHOSPHATIDIC ACID (LPA) PRODUCTION INHIBITORS | HOFFMANN LA ROCHE (CH) | 2019-09-04 | — | — | EP | disclosed |
| EP-3122750-A1 | BICYCLIC COMPOUNDS AS AUTOTAXIN (ATX) AND LYSOPHOSPHATIDIC ACID (LPA) PRODUCTION INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2017-02-01 | — | — | EP | disclosed |
| WO-2015144605-A1 | BICYCLIC COMPOUNDS AS AUTOTAXIN (ATX) AND LYSOPHOSPHATIDIC ACID (LPA) PRODUCTION INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2015-10-01 | — | — | WO | disclosed |