SCHEMBL17112646

SCHEMBL17112646

O=C(O)N1CCC2CN(C(=O)[C@@H]3CCc4[nH]nnc4C3)CC2CC1

nearest known ligand 0.35

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
ATXN2 Q99700 4/20 0.35
HSD11B1 P28845 1/20 0.33
CHRNB2 P17787 1/20 0.33
CHRNB4 P30926 1/20 0.33
CHRNA3 P32297 1/20 0.33
CHRNA7 P36544 1/20 0.33
CHRNA4 P43681 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17112648 1.00 ATXN2 (0.35) ATXN2HSD11B1CHRNB2CHRNB4CHRNA3
SCHEMBL21313833 0.91 CHRNB2 (0.35) ATXN2HSD11B1CHRNB2CHRNB4CHRNA3
SCHEMBL17112561 0.85 CHRNB2 (0.37) ATXN2HSD11B1CHRNB2CHRNB4CHRNA3
SCHEMBL17112559 0.85 CHRNB2 (0.37) ATXN2HSD11B1CHRNB2CHRNB4CHRNA3
SCHEMBL22188655 0.84 CHRNA4 (0.51) CHRNB2CHRNB4CHRNA3CHRNA7CHRNA4
SCHEMBL22188654 0.84 CHRNA4 (0.51) CHRNB2CHRNB4CHRNA3CHRNA7CHRNA4
SCHEMBL17310817 0.84 CHRNA4 (0.51) CHRNB2CHRNB4CHRNA3CHRNA7CHRNA4
SCHEMBL21323354 0.83 HRH4 (0.34) ATXN2HSD11B1CHRNB2CHRNB4CHRNA3
Hydrochloric Acid SCHEMBL17310833 0.83 CHRNA4 (0.50) CHRNB2CHRNB4CHRNA3CHRNA7CHRNA4
Hydrochloric Acid SCHEMBL17310834 0.83 CHRNA4 (0.50) CHRNB2CHRNB4CHRNA3CHRNA7CHRNA4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3122750-A1 BICYCLIC COMPOUNDS AS AUTOTAXIN (ATX) AND LYSOPHOSPHATIDIC ACID (LPA) PRODUCTION INHIBITORS F. Hoffmann-La Roche AG (CH) 2017-02-01 EP disclosed
WO-2015144605-A1 BICYCLIC COMPOUNDS AS AUTOTAXIN (ATX) AND LYSOPHOSPHATIDIC ACID (LPA) PRODUCTION INHIBITORS F. HOFFMANN-LA ROCHE AG (CH) 2015-10-01 WO disclosed