Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNP | P00491 | 1/20 | 0.66 |
| ▸ | LMNA | P02545 | 1/20 | 0.66 |
| ▸ | TP53 | P04637 | 1/20 | 0.66 |
| ▸ | HTT | P42858 | 1/20 | 0.66 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.66 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.66 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.66 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.48 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.48 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.45 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.45 |
| ▸ | NT5E | P21589 | 2/20 | 0.45 |
| ▸ | METTL3 | Q86U44 | 3/20 | 0.43 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21423110 | 1.00 | PNP (0.66) | PNPLMNATP53HTTPDE4D | |
| SCHEMBL17106676 | 1.00 | PNP (0.66) | PNPLMNATP53HTTPDE4D | |
| SCHEMBL21423109 | 1.00 | PNP (0.66) | PNPLMNATP53HTTPDE4D | |
| SCHEMBL17106782 | 0.88 | DNMT1 (0.53) | PNPLMNATP53HTTPDE4D | |
| SCHEMBL12123493 | 0.88 | DNMT1 (0.53) | PNPLMNATP53HTTPDE4D | |
| SCHEMBL12125100 | 0.88 | DNMT1 (0.53) | PNPLMNATP53HTTPDE4D | |
| SCHEMBL17131306 | 0.88 | PDE4D (0.51) | PNPLMNATP53HTTPDE4D | |
| SCHEMBL17106831 | 0.86 | LMNA (0.49) | PNPLMNATP53HTTPDE4D | |
| 2'-Deoxytubercidin SCHEMBL23982321 | 0.81 | METTL3 (0.57) | PNPLMNATP53HTTPDE4D | |
| 2'-Deoxytubercidin SCHEMBL13314431 | 0.81 | METTL3 (0.57) | PNPLMNATP53HTTPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3122752-A1 | 4'-SUBSTITUTED NUCLEOSIDE-DERIVATIVES AS HIV REVERSE TRANSCRIPTASE INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2017-02-01 | — | — | EP | disclosed |
| WO-2015148746-A1 | 4'-SUBSTITUTED NUCLEOSIDE-DERIVATIVES AS HIV REVERSE TRANSCRIPTASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2015-10-01 | — | — | WO | disclosed |