Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLRMT | O00411 | 1/20 | 0.36 |
| ▸ | DOT1L | Q8TEK3 | 5/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.32 |
| ▸ | ACVRL1 | P37023 | 2/20 | 0.31 |
| ▸ | TMPRSS2 | O15393 | 1/20 | 0.31 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17106697 | 1.00 | POLRMT (0.36) | POLRMTDOT1LMAP4K4ACVRL1TMPRSS2 | |
| SCHEMBL17111232 | 1.00 | POLRMT (0.36) | POLRMTDOT1LMAP4K4ACVRL1TMPRSS2 | |
| SCHEMBL17130417 | 0.90 | POLRMT (0.37) | POLRMTDOT1L | |
| SCHEMBL17106845 | 0.90 | POLRMT (0.37) | POLRMTDOT1L | |
| SCHEMBL17106821 | 0.83 | POLRMT (0.32) | POLRMTDOT1L | |
| SCHEMBL26270281 | 0.82 | POLRMT (0.38) | POLRMTDOT1LMAP4K4ACVRL1 | |
| SCHEMBL19412761 | 0.82 | POLRMT (0.38) | POLRMTDOT1LMAP4K4ACVRL1PIK3CD | |
| SCHEMBL19412426 | 0.82 | POLRMT (0.34) | POLRMTDOT1L | |
| SCHEMBL19768739 | 0.82 | POLRMT (0.46) | POLRMTDOT1LMAP4K4TMPRSS2PIK3CD | |
| SCHEMBL19779087 | 0.82 | POLRMT (0.46) | POLRMTDOT1LMAP4K4TMPRSS2PIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3122752-A1 | 4'-SUBSTITUTED NUCLEOSIDE-DERIVATIVES AS HIV REVERSE TRANSCRIPTASE INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2017-02-01 | — | — | EP | claimed |
| WO-2015148746-A1 | 4'-SUBSTITUTED NUCLEOSIDE-DERIVATIVES AS HIV REVERSE TRANSCRIPTASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2015-10-01 | — | — | WO | claimed |