Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLRMT | O00411 | 1/20 | 0.37 |
| ▸ | DOT1L | Q8TEK3 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17106845 | 1.00 | POLRMT (0.37) | POLRMTDOT1L | |
| SCHEMBL17114380 | 0.90 | POLRMT (0.36) | POLRMTDOT1L | |
| SCHEMBL17111232 | 0.90 | POLRMT (0.36) | POLRMTDOT1L | |
| SCHEMBL17106697 | 0.90 | POLRMT (0.36) | POLRMTDOT1L | |
| SCHEMBL19412426 | 0.89 | POLRMT (0.34) | POLRMTDOT1L | |
| SCHEMBL17106779 | 0.84 | SLC28A1 (0.30) | — | |
| SCHEMBL17106714 | 0.83 | POLRMT (0.35) | POLRMTDOT1L | |
| SCHEMBL17106723 | 0.83 | POLRMT (0.33) | POLRMTDOT1L | |
| SCHEMBL19412761 | 0.83 | POLRMT (0.38) | POLRMTDOT1L | |
| SCHEMBL26270281 | 0.83 | POLRMT (0.38) | POLRMTDOT1L |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015148746-A1 | 4'-SUBSTITUTED NUCLEOSIDE-DERIVATIVES AS HIV REVERSE TRANSCRIPTASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2015-10-01 | — | — | WO | disclosed |
| WO-2015143712-A1 | 4'-SUBSTITUTED NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2015-10-01 | — | — | WO | disclosed |