Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DOT1L | Q8TEK3 | 3/20 | 0.33 |
| ▸ | POLRMT | O00411 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17106728 | 0.92 | DOT1L (0.33) | DOT1LPOLRMT | |
| SCHEMBL25400732 | 0.90 | DOT1L (0.38) | DOT1LPOLRMT | |
| SCHEMBL17106684 | 0.90 | DOT1L (0.35) | DOT1LPOLRMT | |
| SCHEMBL26282567 | 0.90 | DOT1L (0.38) | DOT1LPOLRMT | |
| SCHEMBL30560912 | 0.83 | ADRB1 (0.40) | DOT1LPOLRMT | |
| SCHEMBL24606235 | 0.83 | ADRB1 (0.40) | DOT1LPOLRMT | |
| SCHEMBL22972736 | 0.83 | ADRB1 (0.40) | DOT1LPOLRMT | |
| SCHEMBL25008844 | 0.83 | ADRB1 (0.40) | DOT1LPOLRMT | |
| SCHEMBL10154373 | 0.83 | ADRB1 (0.40) | DOT1LPOLRMT | |
| SCHEMBL17106826 | 0.78 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3122752-A1 | 4'-SUBSTITUTED NUCLEOSIDE-DERIVATIVES AS HIV REVERSE TRANSCRIPTASE INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2017-02-01 | — | — | EP | disclosed |
| WO-2015148746-A1 | 4'-SUBSTITUTED NUCLEOSIDE-DERIVATIVES AS HIV REVERSE TRANSCRIPTASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2015-10-01 | — | — | WO | disclosed |