Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14332329 | 0.78 | THRA (0.38) | THRATHRB | |
| SCHEMBL22297140 | 0.75 | NCF1 (0.38) | — | |
| SCHEMBL7155825 | 0.74 | — | — | |
| SCHEMBL25962108 | 0.72 | — | — | |
| SCHEMBL4654339 | 0.72 | THRA (0.36) | THRATHRB | |
| SCHEMBL5210963 | 0.71 | — | — | |
| SCHEMBL24449906 | 0.70 | THRA (0.39) | THRATHRB | |
| SCHEMBL13508318 | 0.70 | THRA (0.39) | THRATHRB | |
| SCHEMBL24449555 | 0.70 | THRA (0.39) | THRATHRB | |
| SCHEMBL12037115 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2536410-B1 | SUBSTITUTED PYRIMIDINE DERIVATIVES AND THEIR USE IN TREATING VIRAL INFECTIONS | MERCK SHARP & DOHME (US) | 2015-09-23 | — | — | EP | disclosed |