SCHEMBL17119925

SCHEMBL17119925

O=C(O)c1ccc(N2CC[C@H](F)C2)nc1Cl

nearest known ligand 0.44

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
P2RX7 Q99572 6/20 0.44
PRKAB2 O43741 5/20 0.41
PRKAG1 P54619 5/20 0.41
PRKAA2 P54646 5/20 0.41
PRKAA1 Q13131 5/20 0.41
PRKAG3 Q9UGI9 5/20 0.41
PRKAG2 Q9UGJ0 5/20 0.41
PRKAB1 Q9Y478 5/20 0.41
HSD11B1 P28845 4/20 0.39
LMNA P02545 1/20 0.39
HTT P42858 1/20 0.39
PTGER4 P35408 2/20 0.38
MAT2A P31153 1/20 0.37
MAT1A Q00266 1/20 0.37
KEAP1 Q14145 1/20 0.36
NFE2L2 Q16236 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15630647 0.87 P2RX7 (0.41) P2RX7PRKAB2PRKAG1PRKAA2PRKAA1
Hydrochloric Acid SCHEMBL5223250 0.83 MEN1 (0.51) PRKAB2PRKAG1PRKAA2PRKAA1PRKAG3
SCHEMBL16613209 0.77 BTK (0.52) MAT2A
SCHEMBL17310967 0.76 P2RX7 (0.64) P2RX7
SCHEMBL17310964 0.76 P2RX7 (0.64) P2RX7
SCHEMBL17311006 0.76 P2RX7 (0.64) P2RX7
SCHEMBL31297178 0.74 SHMT2 (0.59) HTT
SCHEMBL16597831 0.73 MEN1 (0.52) LMNAHTT
SCHEMBL15630491 0.73 NOTUM (0.55)
SCHEMBL21262189 0.72 P2RX7 (0.43) P2RX7MAT2AMAT1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9946847-B2 Libraries of compounds having desired properties and methods for making and using them BIOBLOCKS INC. (US) 2018-04-17 US disclosed
US-9946847-B2 Libraries of compounds having desired properties and methods for making and using them BIOBLOCKS INC. (US) 2018-04-17 US disclosed
US-20150269356-A1 LIBRARIES OF COMPOUNDS HAVING DESIRED PROPERTIES AND METHODS FOR MAKING AND USING THEM BIOBLOCKS INC (US) 2015-09-24 US disclosed
US-20150269356-A1 LIBRARIES OF COMPOUNDS HAVING DESIRED PROPERTIES AND METHODS FOR MAKING AND USING THEM BIOBLOCKS INC (US) 2015-09-24 US disclosed