Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 13/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 8/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 6/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.36 |
| ▸ | DPP4 | P27487 | 2/20 | 0.33 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.33 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.31 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15436348 | 0.89 | HSD11B1 (0.43) | HSD11B1CYP2C9CYP2C19CYP3A4DPP4 | |
| SCHEMBL15436310 | 0.84 | HSD11B1 (0.45) | HSD11B1CYP2C9CYP2C19CYP3A4PTGDR2 | |
| SCHEMBL17120364 | 0.84 | HSD11B1 (0.46) | HSD11B1CYP2C9CYP2C19CYP3A4DPP4 | |
| SCHEMBL17120436 | 0.82 | CREBBP (0.40) | HSD11B1CYP2C9CYP2C19CYP3A4DPP4 | |
| SCHEMBL15241457 | 0.82 | HSD11B1 (0.42) | HSD11B1CYP2C9CYP2C19CYP3A4DPP4 | |
| SCHEMBL13624909 | 0.81 | HSD11B1 (0.44) | HSD11B1CYP2C9CYP2C19CYP3A4 | |
| SCHEMBL17120312 | 0.81 | HSD11B1 (0.44) | HSD11B1CYP2C9CYP2C19CYP3A4 | |
| SCHEMBL15959067 | 0.81 | HSD11B1 (0.45) | HSD11B1CYP2C9CYP2C19CYP3A4 | |
| SCHEMBL15241450 | 0.81 | HSD11B1 (0.45) | HSD11B1CYP2C9CYP2C19CYP3A4 | |
| SCHEMBL15436303 | 0.80 | CREBBP (0.36) | HSD11B1CYP2C9CYP2C19CYP3A4DPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2687525-B1 | CYCLIC INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | BOEHRINGER INGELHEIM INT (DE) | 2015-09-23 | — | — | EP | disclosed |