Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK12 | Q9NYV4 | 8/20 | 0.42 |
| ▸ | CDK13 | Q14004 | 6/20 | 0.42 |
| ▸ | CDK7 | P50613 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13490375 | 0.81 | RAB9A (0.46) | CDK12CDK13KMT2AMEN1ALDH1A1 | |
| SCHEMBL13490572 | 0.78 | P2RY12 (0.43) | KMT2AMEN1RAB9ASMN1; SMN2MAPK1 | |
| SCHEMBL13490590 | 0.77 | MEN1 (0.44) | KMT2AMEN1RAB9ASMN1; SMN2CYP3A4 | |
| SCHEMBL171287 | 0.76 | RAB9A (0.43) | CDK12CDK13KMT2AMEN1ALDH1A1 | |
| SCHEMBL171515 | 0.74 | KDM1A (0.43) | KMT2AMEN1ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL26986892 | 0.73 | CDK12 (0.45) | CDK12CDK13CDK7 | |
| SCHEMBL31420092 | 0.73 | CDK12 (0.45) | CDK12CDK13CDK7 | |
| SCHEMBL13490575 | 0.73 | MEN1 (0.44) | KMT2AMEN1RAB9ASMN1; SMN2CYP3A4 | |
| SCHEMBL169438 | 0.73 | MEN1 (0.41) | KMT2AMEN1ALDH1A1RAB9AMAPT | |
| SCHEMBL13490589 | 0.72 | MEN1 (0.42) | KMT2AMEN1RAB9ASMN1; SMN2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2426120-A1 | Pyridyltetrahydropyridines and pyridylpiperidines, and method of manufacturing them | Fujifilm Finechemicals Co., Ltd. (JP) | 2012-03-07 | — | — | EP | disclosed |
| US-7632950-B2 | Pyridyltetrahydropyridines and pyridylpiperidines and method of manufacturing them | FUJIFILM FINECHEMICALS CO., LTD (JP) | 2009-12-15 | — | — | US | disclosed |